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SHR Neuro Cancer Cardio Lipid Metab Microb

Worel, N; Rosskopf, K; Neumeister, P; Kasparu, H; Nachbaur, D; Russ, G; Namberger, K; Witt, V; Schloegl, E; Zojer, N; Linkesch, W; Kalhs, P; Greinix, HT.
Plerixafor and granulocyte-colony-stimulating factor (G-CSF) in patients with lymphoma and multiple myeloma previously failing mobilization with G-CSF with or without chemotherapy for autologous hematopoietic stem cell mobilization: the Austrian experience on a named patient program.
Transfusion. 2011; 51(5):968-975 Doi: 10.1111/j.1537-2995.2010.02896.x
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Co-authors Med Uni Graz: Greinix Hildegard; Linkesch Werner; Neumeister Peter; Rosskopf Konrad
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Abstract:: Plerixafor in combination with granulocyte-colony-stimulating factor (G-CSF) has been shown to enhance stem cell mobilization in patients with multiple myeloma, non-Hodgkin's lymphoma, and Hodgkin's disease who demonstrated with previous mobilization failure. In this named patient program we report the Austrian experience in insufficiently mobilizing patients. Twenty-seven patients from eight Austrian centers with a median (range) age of 58 (19-70) years (18 female, nine male) were included in the study. Plerixafor was limited to patients with previous stem cell mobilization failure and was given in the evening of Day 4 of G-CSF application. A median increase of circulating CD34+ cells within 10 to 11 hours from administration of plerixafor by a factor of 4.7 over baseline was noted. Overall, 20 (74%) patients reached more than 10 × 10(6) CD34+ cells/L in the peripheral blood, resulting in 17 (63%) patients collecting at least 2 × 10(6) CD34+ cells/kg body weight (b.w.; median, 2.6 × 10(6) CD34+ cells/kg b.w.; range, 0.08 × 10(6) -8.07 × 10(6) ). Adverse events of plerixafor were mild to moderate and consisted of gastrointestinal side effects and local reactions at the injection site. Thirteen (48%) patients underwent autologous transplantation receiving a median of 2.93 × 10(6) CD34+ cells/kg (range, 1.46 × 10(6) -5.6 × 10(6) ) and showed a trilinear engraftment with a median neutrophil recovery on Day 12 and a platelet recovery on Day 14. Our study confirms previous investigations showing that plerixafor in combination with G-CSF is an effective and well-tolerated mobilization regimen with the potential of successful stem cell collection in patients with previous mobilization failure. © 2010 American Association of Blood Banks.
Find related publications in this database (using NLM MeSH Indexing): Adolescent -; Adult -; Aged -; Antigens, CD34 - metabolism; Antigens, CD34 -; Combined Modality Therapy -; Drug Therapy, Combination -; Female -; Granulocyte Colony-Stimulating Factor - administration & dosage; Hematopoietic Stem Cell Mobilization - methods; Hematopoietic Stem Cell Transplantation - methods; Hematopoietic Stem Cells - cytology Hematopoietic Stem Cells - metabolism; Heterocyclic Compounds - administration & dosage; Humans -; Immunoglobulin G - therapeutic use; Leukapheresis -; Lymphoma - drug therapy; Male -; Melphalan - therapeutic use; Middle Aged -; Multiple Myeloma - drug therapy; Receptors, CXCR4 - antagonists & inhibitors; Transplantation, Autologous -; Young Adult -