Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
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SHR Neuro Krebs Kardio Lipid Stoffw Microb
Sievers, C; Klotsche, J; Pieper, L; Schneider, HJ; Marz, W; Wittchen, HU; Stalla, GK; Mantzoros, C.
Low testosterone levels predict all-cause mortality and cardiovascular events in women: a prospective cohort study in German primary care patients.
Eur J Endocrinol. 2010; 163(4):699-708
Doi: 10.1530/EJE-10-0307
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- Co-Autor*innen der Med Uni Graz
- März Winfried
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- Abstract:
- OBJECTIVE: Although associations between testosterone and cardiovascular (CV) morbidity in women have been proposed, no large prospective study has evaluated potential associations between testosterone and mortality in women. The objective was to determine whether baseline testosterone levels in women are associated with future overall or CV morbidity and mortality. DESIGN: Prospective cohort study with a 4.5-year follow-up period. METHODS: From a representative sample of German primary care practices, 2914 female patients between 18 and 75 years were analyzed for the main outcome measures: CV risk factors, CV diseases, and all-cause mortality. RESULTS: At baseline, the study population was aged 57.96±14.37 years with a mean body mass index of 26.71±5.17 kg/m(2). No predictive value of total testosterone for incident CV risk factors or CV diseases was observed in logistic regressions. Patients with total testosterone levels in the lowest quintile Q1, however, had a higher risk to die of any cause or to develop a CV event within the follow-up period compared to patients in the collapsed quintiles Q2-Q5 in crude and adjusted Cox regression models (all-cause mortality: Q2-Q5 versus Q1: crude hazard ratios (HR) 0.49, 95% confidence interval (CI) 0.33-0.74; adjusted HR 0.62, 95% CI 0.42-0.939; CV events: Q2-Q5 versus Q1: crude HR 0.54, 95% CI 0.38-0.77; adjusted HR 0.68, 95% CI 0.48-0.97). Kaplan-Meier curves revealed similar data. CONCLUSIONS: Low baseline testosterone in women is associated with increased all-cause mortality and incident CV events independent of traditional risk factors.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent -
- Adult -
- Aged -
- Analysis of Variance -
- Cardiovascular Diseases - blood Cardiovascular Diseases - mortality
- Chromatography, Liquid -
- Cohort Studies -
- Female -
- Humans -
- Middle Aged -
- Proportional Hazards Models -
- Prospective Studies -
- Risk Factors -
- Tandem Mass Spectrometry -
- Testosterone - blood
- Young Adult -