Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Enzinger, C; Ropele, S; Gattringer, T; Langkammer, C; Schmidt, R; Fazekas, F.
High-grade internal carotid artery stenosis and chronic brain damage: a volumetric magnetic resonance imaging study.
Cerebrovasc Dis. 2010; 30(6): 540-546.
Doi: 10.1159/000319025
Web of Science
PubMed
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FullText_MUG
- Führende Autor*innen der Med Uni Graz
- Enzinger Christian
- Fazekas Franz
- Co-Autor*innen der Med Uni Graz
- Gattringer Thomas
- Langkammer Christian
- Ropele Stefan
- Schmidt Reinhold
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- Abstract:
- Background: Experimental data suggest that high-grade vascular stenosis may induce chronic cerebral tissue damage. Methods: We tested this hypothesis in 97 patients with a >= 70% unilateral internal carotid artery (ICA) stenosis (mean age: 69.1 +/- 10.2 years), comparing intraindividual side-to-side differences in hemispheric brain and white matter hyperintensity (WMH) volumes. Patients with a supratentorial infarct exceeding 1.5 cm in diameter were excluded. Results: Overall, the median WMH volume was greater in the hemisphere ipsilateral to the stenotic ICA (1.13 +/- 2.65 vs. 0.77 +/- 2.26 cm(3); p = 0.005), but there were no differences in hemispheric brain volumes between the stenotic and nonstenotic sides. In the subgroup of patients with moderate and severe WMH (n = 41), the hemispheric volume ipsilateral to the stenotic ICA was significantly smaller (543.46 +/- 22.17 vs. 548.66 +/- 26.7 cm(3); p = 0.03). Multivariate linear regression analysis revealed an independent effect of WMH grade on interhemispheric volume differences relative to the side of stenosis. Conclusions: Chronic tissue damage may occur in a subset of individuals with >= 70% ICA stenosis, globally exhibiting more extensive WMH. Copyright (C) 2010 S. Karger AG, Basel
- Find related publications in this database (using NLM MeSH Indexing)
- Aged -
- Analysis of Variance -
- Analysis of Variance -
- Brain Diseases - etiology Brain Diseases - pathology
- Carotid Artery, Internal - pathology Carotid Artery, Internal - ultrasonography
- Carotid Stenosis - complications Carotid Stenosis - pathology Carotid Stenosis - ultrasonography
- Cerebrum - pathology
- Chi-Square Distribution -
- Chronic Disease -
- Female -
- Humans -
- Linear Models -
- Magnetic Resonance Angiography -
- Magnetic Resonance Imaging -
- Male -
- Middle Aged -
- Organ Size -
- Retrospective Studies -
- Severity of Illness Index -
- Ultrasonography, Doppler, Duplex -
- Find related publications in this database (Keywords)
- Atrophy
- Brain damage
- Carotid stenosis
- White matter hyperintensities