Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Becker, JC; Schrama, D; Houben, R.
Merkel cell carcinoma.
Cell Mol Life Sci. 2009; 66(1):1-8
Doi: 10.1007/s00018-008-8483-6
Web of Science
PubMed
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- Leading authors Med Uni Graz
- Becker Jürgen Christian
- Co-authors Med Uni Graz
- Schrama David
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- Abstract:
- Merkel cell carcinoma (MCC) is a highly aggressive neuroendocrine carcinoma of the skin. More than one-third of MCC patients will die from this cancer, making it twice as lethal as malignant melanoma. Despite the fact that MCC is still a very rare tumor, its incidence is rapidly increasing; the American Cancer Society estimates for 2008 almost 1,500 new cases in the USA. These clinical observations are especially disturbing as the pathogenesis of MCC is not yet fully understood; however, a number of recent reports contribute to a better understanding of its pathogenesis. Here we describe findings regarding the role of Wnt, MAPK and Akt signaling as well as possible aberrations in the p14ARF/p53/RB tumor suppressor network in MCC. Most important, and possibly with high impact on future therapeutic approaches is the demonstration that a polyomavirus has frequently integrated in the genome of the MCC cells prior to tumor development.
- Find related publications in this database (using NLM MeSH Indexing)
- Carcinoma, Merkel Cell - epidemiology Carcinoma, Merkel Cell - etiology Carcinoma, Merkel Cell - metabolism Carcinoma, Merkel Cell - pathology
- Humans -
- Polyomavirus - isolation and purification Polyomavirus - pathogenicity
- Signal Transduction -
- Skin Neoplasms - epidemiology Skin Neoplasms - etiology Skin Neoplasms - metabolism Skin Neoplasms - pathology
- Find related publications in this database (Keywords)
- Neuroendocrine carcinoma of the skin
- epidemiology
- carcinogenesis
- signal transduction
- polyoma-virus