Medizinische Universität Graz - Research portal
Selected Publication:
Schrama, D; Straten, P; Bröcker, EB; Reisfeld, RA; Becker, JC.
Cytokine fusion protein treatment.
Recent Results Cancer Res. 2002; 160(20):185-194
Doi: 10.1007/978-3-642-59410-6_22
PubMed
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- Leading authors Med Uni Graz
- Becker Jürgen Christian
- Schrama David
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- Abstract:
- Mice suffering from melanoma can be cured by treatment with a recombinant antibody-lymphotoxin-alpha fusion protein. In order to characterize the involvement of T cells in this syngeneic tumor model, the T cell receptor repertoire was analyzed both quantitatively and qualitatively. In this connection, quantitative analysis of the T cell receptors displayed only a modest overexpression in some of the variable beta chain families over the course of therapy. Clonotypic mapping, however, revealed a marked increase in the number of clonally expanded T cells among the tumor-infiltrating T cells, suggesting a specific activation.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Clone Cells -
- Cytokines - therapeutic use
- Lymphotoxin-alpha - therapeutic use
- Melanoma, Experimental - therapy
- Mice -
- Mice, Inbred C57BL -
- Recombinant Fusion Proteins - therapeutic use
- Reverse Transcriptase Polymerase Chain Reaction -
- T-Lymphocytes - immunology
- Tumor Cells, Cultured -