Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Becker, JC; Schrama, D; Bröcker, EB; Houben, R.
Kinase inhibitors for the therapy of malignant melanoma
J Dtsch Dermatol Ges. 2005; 3(10):762-767
Doi: 10.1111/j.1610-0387.2005.05016.x
PubMed
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- Führende Autor*innen der Med Uni Graz
- Becker Jürgen Christian
- Co-Autor*innen der Med Uni Graz
- Schrama David
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- Abstract:
- Recent results from basic and translational research on the causes and mechanisms of melanoma genesis and progression will impact on future therapeutic approaches. The increasing understanding of the molecular pathology of malignant disease and the detailed analysis of the signal transduction pathways involved allows specific intervention with these oncogenic events. These interventions address the molecules associated with or responsible for the malignant transformation and have therefore been termed "targeted therapy". The present review focuses on the therapeutic options involving modulation of the Ras/MAPK- and PI3K/AKT-signal transduction pathways.
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