Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Rollison, DE; Giuliano, AR; Becker, JC.
New Virus Associated With Merkel Cell Carcinoma Development
J NATL COMPR CANCER NETW. 2010; 8(8): 874-880.
Doi: 10.6004/jnccn.2010.0064
Web of Science
PubMed
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FullText_MUG
- Co-Autor*innen der Med Uni Graz
- Becker Jürgen Christian
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- Abstract:
- Merkel cell carcinoma (MCC) is a rare, aggressive neuroendocrine malignancy of the skin with an annual incidence in the United States of 0.34 and 0.17 per 100,000 men and women, respectively. MCC incidence increases with age, is higher among men and whites, and positively correlates with solar ultraviolet (UV) index, suggesting UV radiation exposure may play a role in the development of MCC. MCC incidence rates are also higher among severely immunosuppressed populations, including people who have undergone organ transplantation, have lymphoma, and are HIV-infected. Given the increased risk for MCC observed with immunosuppression and the established associations between viral infections and other cancers that occur more often in immunosuppressed populations, MCC was a prime cancer candidate for a viral cause. Subsequent investigation discovered a genome encompassing 5387 base pairs of a new polyomavirus, subsequently named the Merkel cell polyomavirus.
- Find related publications in this database (using NLM MeSH Indexing)
- Carcinoma, Merkel Cell - mortality Carcinoma, Merkel Cell - virology
- DNA, Viral - analysis
- Female -
- Humans -
- Male -
- Polyomavirus - isolation and purification
- Skin Neoplasms - mortality Skin Neoplasms - virology
- Viral Load -
- Find related publications in this database (Keywords)
- Merkel cell carcinoma
- Merkel cell polyomavirus
- DNA detection
- T-antigen expression
- seropositivity