Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Bernecker, C; Pailer, S; Kieslinger, P; Horejsi, R; Möller, R; Lechner, A; Wallner-Blazek, M; Weiss, S; Fazekas, F; Truschnig-Wilders, M; Gruber, HJ.
Increased matrix metalloproteinase activity is associated with migraine and migraine-related metabolic dysfunctions.
Eur J Neurol. 2011; 18(4): 571-576.
Doi: 10.1111/j.1468-1331.2010.03205.x
Web of Science
PubMed
FullText
FullText_MUG
- Führende Autor*innen der Med Uni Graz
- Bernecker Claudia
- Co-Autor*innen der Med Uni Graz
- Fazekas Franz
- Gruber Hans-Jürgen
- Horejsi Renate
- Kieslinger Petra
- Lechner Anita
- Möller Reinhard
- Pailer Sabine
- Truschnig-Wilders Martini
- Wallner-Blazek Mirja
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- Matrix metalloproteinases (MMPs) and their inhibitors (TIMPs) are discussed to be involved in the pathophysiology of migraine. Moreover, MMPs may also be involved in migraine-related metabolic alterations like an atherogenic lipid profile and hyperinsulinemia. The aim of this study was to investigate the impact of MMPs and TIMPs on migraine with and without aura and related metabolic dysfunctions. MMP activity, six MMPs and three TIMPs, parameters of the insulin and lipid metabolism as well as anthropometric parameters were determined in 124 non-obese subjects. We found highly significant increased MMP activity in migraine patients independent of aura symptoms, which was associated with migraine with an odds ratio of 7.57. Interestingly, none of the determined MMPs and TIMPs showed significant different serum levels between migraine patients and healthy controls. We found significant correlations between MMP activity and parameters of the insulin and lipid metabolism, like Homeostasis Model Assessment index (HOMA index), cholesterol, triglycerides, and oxidized LDL. We show here that increased MMP activity is tightly associated with migraine and migraine-related hyperinsulinemia and atherogenic lipid alterations. Our findings represent a new pathophysiological mechanism, which may be of clinical relevance, especially in regard to therapeutic approaches using MMP inhibitors. © 2010 The Author(s). European Journal of Neurology © 2010 EFNS.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Blood Glucose -
- Cholesterol - blood
- Enzyme-Linked Immunosorbent Assay -
- Female -
- Humans -
- Hyperinsulinism - physiopathology
- Lipids - blood
- Male -
- Matrix Metalloproteinases - blood
- Migraine Disorders - enzymology
- Tissue Inhibitor of Metalloproteinases - metabolism
- Find related publications in this database (Keywords)
- hyperinsulinemia
- migraine
- matrix metalloproteinases
- tissue inhibitors of metalloproteinases