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SHR Neuro Cancer Cardio Lipid Metab Microb

Volpato, S; Vigna, GB; McDermott, MM; Cavalieri, M; Maraldi, C; Lauretani, F; Bandinelli, S; Zuliani, G; Guralnik, JM; Fellin, R; Ferrucci, L.
Lipoprotein(a), inflammation, and peripheral arterial disease in a community-based sample of older men and women (the InCHIANTI study).
Am J Cardiol. 2010; 105(12):1825-1830 Doi: 10.1016/j.amjcard.2010.01.370 [OPEN ACCESS]
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Co-authors Med Uni Graz: Cavalieri Margherita
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Abstract:: Lipoprotein(a) (Lp[a]) may represent an independent risk factor for peripheral arterial disease of the lower limbs (LL-PAD), but prospective data are scant. We estimated the association between baseline Lp(a) with prevalent and incident LL-PAD in older subjects from the InCHIANTI Study. LL-PAD, defined as an ankle-brachial index <0.90, was assessed at baseline and over a 6-year follow-up in a sample of 1,002 Italian subjects 60 to 96 years of age. Plasma Lp(a) and potential traditional and novel cardiovascular risk factors (including a score based on relevant inflammatory markers) were entered in multivariable models to assess their association with prevalent and incident LL-PAD. At baseline, Lp(a) concentration was directly related to the number of increased inflammatory markers (p <0.05). There were 125 (12.5%) prevalent cases of LL-PAD and 57 (8.3%) incident cases. After adjustment for potential confounders, participants in the highest quartile of the Lp(a) distribution (>/=32.9 mg/dl) were more likely to have LL-PAD compared to those in the lowest quartile (odds ratio [OR] 1.83, 95% confidence interval [CI] 1.01 to 3.33). The association was stronger (OR 3.80, 95% CI 1.50 to 9.61) if LL-PAD was defined by harder criteria, namely an ankle-brachial index <0.70. Compared to subjects in the lowest Lp(a) quartile, those in the highest quartile showed a somewhat increased risk of incident LL-PAD (lowest quartile 7.7%, highest quartile 10.8%), but the association was not statistically significant (OR 1.52, 95% CI 0.71 to 3.22). In conclusion, Lp(a) is an independent LL-PAD correlate in the cross-sectional evaluation, but further prospective studies in larger populations, with longer follow-up and more definite LL-PAD ranking, might be needed to establish a longitudinal association.
Find related publications in this database (using NLM MeSH Indexing): Age Distribution -; Age Factors -; Aged -; Aged, 80 and over -; Biological Markers - blood; Blood Pressure -; Brachial Artery - physiopathology Brachial Artery - ultrasonography; Enzyme-Linked Immunosorbent Assay -; Female -; Follow-Up Studies -; Humans -; Incidence -; Inflammation - blood Inflammation - epidemiology; Italy - epidemiology; Lipoprotein(a) - blood; Male -; Middle Aged -; Peripheral Vascular Diseases - blood Peripheral Vascular Diseases - epidemiology Peripheral Vascular Diseases - physiopathology; Prevalence -; Prognosis -; Prospective Studies -; Severity of Illness Index -; Sex Distribution -; Tibial Arteries - physiopathology Tibial Arteries - ultrasonography; Time Factors -; Ultrasonography, Doppler -; Urban Population -