Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Zuliani, G; Cavalieri, M; Galvani, M; Volpato, S; Cherubini, A; Bandinelli, S; Corsi, AM; Lauretani, F; Guralnik, JM; Fellin, R; Ferrucci, L.
Relationship between low levels of high-density lipoprotein cholesterol and dementia in the elderly. The InChianti study.
J Gerontol A Biol Sci Med Sci. 2010; 65(5):559-564
Doi: 10.1093/gerona/glq026
[OPEN ACCESS]
Web of Science
PubMed
FullText
FullText_MUG
- Co-authors Med Uni Graz
- Cavalieri Margherita
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- BACKGROUND: To evaluate the association between plasma lipid fractions and the prevalence of dementia in a large sample of Italian older individuals. METHODS: A total of 1051 older community-dwelling individuals (age >/=65 years), enrolled in the InChianti study, were included. Diagnosis of dementia was established at baseline and at the 3-year follow-up using Diagnostic and Statistical Manual of Mental Disorder (Fourth Edition) criteria. Plasma lipids were measured by standardized methods at baseline and after 3 years. RESULTS: At baseline, 61 individuals (5.8%) were affected by dementia. Demented individuals showed significantly lower total cholesterol (TC), nonhigh-density lipoprotein cholesterol, and high-density lipoprotein cholesterol (HDL-C) levels compared with controls; no differences were found in triglycerides (TG) and lipoprotein (a) levels. Of the 819 subjects reevaluated at the 3-year follow-up, 81 (9.9%) received a new diagnosis of dementia. Again, demented subjects were characterized by significantly lower TC, non-HDL-C, and HDL-C levels compared with controls, thus confirming the baseline findings. At multivariate logistic regression analysis, HDL-C levels (odds ratio: 0.96, 95% confidence interval: 0.93-0.99), but not TG and non-HDL-C, were associated with dementia independent of important confounders including age, gender, apo E phenotype, stroke, weight loss, interleukin 6 levels, and ankle-brachial index. CONCLUSIONS: Among community-dwelling older people, individuals affected by dementia showed significantly lower TC, non-HDL-C, and HDL-C levels; however, at multivariate analysis, only HDL-C was associated with dementia. Our results suggest the existence of an independent relationship between dementia and low HDL-C levels.
- Find related publications in this database (using NLM MeSH Indexing)
- Age Factors -
- Aged -
- Aged, 80 and over -
- Ankle Brachial Index -
- Apolipoproteins E - genetics
- Cholesterol - blood
- Cholesterol, HDL - blood
- Dementia - blood Dementia - epidemiology
- Educational Status -
- Female -
- Humans -
- Italy - epidemiology
- Logistic Models -
- Male -
- Multivariate Analysis -
- Polymorphism, Genetic - genetics
- Prevalence -
- Psychological Tests -
- Risk Factors -
- Sex Factors -
- Statistics, Nonparametric -
- Find related publications in this database (Keywords)
- Dementia
- Lipids
- Elderly