Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
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Pollheimer, MJ; Kornprat, P; Lindtner, RA; Harbaum, L; Schlemmer, A; Rehak, P; Langner, C.
Tumor necrosis is a new promising prognostic factor in colorectal cancer.
Hum Pathol. 2010; 41(12):1749-1757
Doi: 10.1016/j.humpath.2010.04.018
Web of Science
PubMed
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- Führende Autor*innen der Med Uni Graz
- Langner Cord
- Pollheimer Marion
- Co-Autor*innen der Med Uni Graz
- Kornprat Peter
- Rehak Peter
- Schlemmer Andrea
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- Abstract:
- The prognostic significance of tumor necrosis in colorectal cancer is unclear. Our study aimed to analyze the prognostic value of tumor necrosis with respect to progression-free and cancer-specific survival and to relate findings to expression of proteins involved in the control of cancer cell death, such as p53 and bcl-2. A total of 381 colorectal cancer specimens were retrospectively reevaluated. The extent of tumor necrosis was semiquantitatively assessed and recorded as either absent, focal (≤10% of the tumor area), moderate (10%-30%), or extensive (≥30%). Expression of p53 and bcl-2 was assessed immunohistochemically and recorded as either positive (using a cutoff value of 10%) or negative. In addition, mismatch repair protein status was assessed by immunohistochemistry using antibodies directed against hMLH1, hMSH2, and hMSH6. Tumor necrosis was observed in 365 (96%) cases, with 180 (47%) tumors showing focal necrosis, 119 (31%) moderate necrosis, and 66 (17%) extensive necrosis, respectively. Extent of necrosis was significantly associated with high T classification (P < .001), high N classification (P = .005), high International Union Against Cancer stage (P < .001), poor tumor differentiation (P < .001), large tumor size (P < .001), and blood vessel invasion (P = .01). No association of tumor necrosis with expression of p53, bcl-2, and mismatch repair protein status was observed. Tumor necrosis proved to be an independent prognostic variable with respect to progression-free and cancer-specific survival. In conclusion, tumor necrosis showed significant impact on prognosis of colorectal cancer patients. Its presence is readily assessable in hematoxylin and eosin-stained sections and should therefore routinely be commented upon in the pathology report. Copyright © 2010 Elsevier Inc. All rights reserved.
- Find related publications in this database (using NLM MeSH Indexing)
- Adenocarcinoma - metabolism Adenocarcinoma - mortality Adenocarcinoma - pathology
- Adult -
- Aged -
- Aged, 80 and over -
- Aged, 80 and over - epidemiology
- Biomarkers, Tumor - metabolism
- Colorectal Neoplasms - metabolism Colorectal Neoplasms - mortality Colorectal Neoplasms - pathology
- DNA-Binding Proteins - metabolism
- Disease Progression -
- Female -
- Humans -
- Immunohistochemistry -
- Male -
- Middle Aged -
- Necrosis -
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- Proto-Oncogene Proteins c-bcl-2 - metabolism
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- Tumor Suppressor Protein p53 - metabolism
- Find related publications in this database (Keywords)
- Colorectal cancer
- Tumor necrosis
- Immunohistochemistry
- Prognosis
- Survival