Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Haas, HS; Linecker, A; Pfragner, R; Sadjak, A.
Peripheral glutamate signaling in head and neck areas.
Head Neck. 2010; 32(11): 1554-1572.
Doi: 10.1002/hed.21438
Web of Science
PubMed
FullText
FullText_MUG
- Führende Autor*innen der Med Uni Graz
- Haas Helga Susanne
- Co-Autor*innen der Med Uni Graz
- Pfragner Roswitha
- Sadjak Anton
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- Abstract:
- The major excitatory neurotransmitter glutamate is also found in the periphery in an increasing number of nonexcitable cells. In line with this it became apparent that glutamate can regulate a broad array of peripheral biological responses, as well. Of particular interest is the discovery that glutamate receptor reactive reagents can influence tumor biology. However, the knowledge of glutamate signaling in peripheral tissues is still incomplete and, in the case of head and neck areas, is almost lacking. The roles of glutamate signaling pathways in these regions are manifold and include orofacial pain, periodontal bone production, skin and airway inflammation, as well as salivation. Furthermore, the interrelations between glutamate and cancers in the oral cavity, thyroid gland, and other regions are discussed. In summary, this review shall strengthen the view that glutamate receptor reagents may also be promising targets for novel therapeutic concepts suitable for a number of diseases in peripheral tissues. The contents of this review cover the following sections: Introduction; The "Glutamate System"; The Taste of Glutamate; Glutamate Signaling in Dental Regions; Glutamate Signaling in Head and Neck Areas; Glutamate Signaling in Head and Neck Cancer; A Brief Overview of Glutamate Signaling in Other Cancers; and Conclusion.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Cell Proliferation - drug effects
- Excitatory Amino Acid Antagonists - pharmacology
- Glutamic Acid - metabolism
- Head and Neck Neoplasms - metabolism
- Humans -
- Oral Surgical Procedures -
- Receptors, Glutamate - physiology
- Receptors, N-Methyl-D-Aspartate - antagonists and inhibitors
- Salivary Glands - innervation
- Signal Transduction - physiology
- Skin - metabolism
- Taste - physiology
- Taste Buds - metabolism
- Thyroid Gland - metabolism
- Find related publications in this database (Keywords)
- glutamate
- oral cavity
- dental regions
- thyroid gland
- taste sensation
- cancer