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Novara, G; De Marco, V; Gottardo, F; Dalpiaz, O; Bouygues, V; Galfano, A; Martignoni, G; Patard, JJ; Artibani, W; Ficarra, V.
Independent predictors of cancer-specific survival in transitional cell carcinoma of the upper urinary tract: multi-institutional dataset from 3 European centers.
Cancer. 2007; 110(8): 1715-1722. Doi: 10.1002/cncr.22970 [OPEN ACCESS]
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Co-authors Med Uni Graz: Dalpiaz Orietta
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Abstract:: BACKGROUND. The objective of the current study was to identify variables that were predictive of cancer-specific survival in patients with nonmetastatic transitional cell carcinoma of the upper urinary tract (UUT-TCC). METHODS. Clinical and pathologic data from 269 patients who underwent nephroureterectomy for UUT-TCC from 1989 to 2005 in 3 urologic European centers were collected retrospectively. Log-rank tests and Cox proportional-hazards regression models were used for univariate and multivariate analyses. RESULTS. Two hundred fifty patients underwent nephroureterectomy, and 19 patients underwent concomitant cystectomy for synchronous muscle-invasive bladder cancer. The median follow-up of the whole cohort was 34 months, and the median follow-up of the patients who remained alive and disease-free was 52 months. At follow-up, 57 cancer-related deaths (21.2%) were censored, and 169 patients (62.8%) were alive and disease-free. On univariate analysis, a history of previous bladder cancer, pathologic stage of the primary tumor and lymph nodes, tumor grade, the presence of lymphovascular invasion, tumor site, synchronous muscle-invasive bladder TCC, and turner multifocality were associated with cancer-specific survival probabilities. On multivariate analysis, pathologic stage of the primary tumor and lymph nodes, tumor multifocality within the UUT, synchronous muscle-invasive bladder TCC, and a history of bladder TCC before the diagnosis of UUT-TCC were independent predictors of cancer-specific survival probabilities. CONCLUSIONS. in a multi-institutional dataset of patients who had undergone nephroureterectomy for UUT-TCC, the current results indicated that pathologic stage of the primary tumor and lymph nodes, a history of prior bladder TCC, the presence of synchronous muscle-invasive bladder cancer, and tumor multifocality within the UUT were independent predictors of cancer-specific survival probabilities.
Find related publications in this database (using NLM MeSH Indexing): Aged -; Carcinoma, Transitional Cell - mortality Carcinoma, Transitional Cell - pathology Carcinoma, Transitional Cell - surgery; Databases, Factual -; Disease Progression -; Female -; Follow-Up Studies -; Humans -; Immunohistochemistry -; Kidney Neoplasms - mortality Kidney Neoplasms - pathology Kidney Neoplasms - surgery; Male -; Muscle Neoplasms - pathology Muscle Neoplasms - surgery; Neoplasm Invasiveness - pathology; Neoplasm Recurrence, Local - pathology; Risk Assessment -; Survival Rate -; Urinary Bladder Neoplasms - mortality Urinary Bladder Neoplasms - pathology Urinary Bladder Neoplasms - surgery
Find related publications in this database (Keywords): upper urinary tract transitional cell carcinoma; nephroureterectomy; ureterectomy; bladder cancer; cancer-specific survival