Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
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SHR Neuro Krebs Kardio Lipid Stoffw Microb
Novara, G; Ficarra, V; Alrabi, N; Dalpiaz, O; Martignoni, G; Galfano, A; Cavalleri, S; Artibani, W.
Prognostic factors in a recent series of patients treated with radical cystectomy for bladder cancer.
Urol Int. 2005; 75(1):10-16
Doi: 10.1159/000085920
Web of Science
PubMed
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- Co-Autor*innen der Med Uni Graz
- Dalpiaz Orietta
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- Abstract:
- Objective: To identify the clinical and pathological prognostic factors in a homogeneous series of patients with bladder cancer who had undergone radical cystectomy in the late 1990s. Materials and Methods: We retrospectively analyzed the clinical data of 156 patients who had undergone radical cystectomy and iliac-obturator lymphadenectomy for bladder carcinoma at our department between 1995 and 2001. Results: The mean follow-up was 39.71 +/- 26.2 months. The 5-year overall and cancer-specific c survival rates were 47.2 and 54.7%, respectively. Upper urinary tract obstruction ( p = 0.03), clinical stage of both the primary tumor ( p = 0.0001) and loco-regional lymph nodes ( p = 0.04), pathological stage (2002 TNM) of the primary tumor ( p = 0.0001), pathological loco-regional lymph node involvement ( p = 0.0001), and vascular embolization ( p = 0.005) were significant on univariate analysis. Pathological lymph node involvement ( p = 0.001) and both pathological ( p = 0.022) and clinical stages of the primary tumor (p = 0.002) turned out to be independent predictors of cancer-specific survival. Conclusion: Pathological lymph node involvement,clinical and pathological stage of the primary tumor were the cancer-specific, survival-independent, predictors in our series. Our multivariate analysis data identifi fied pT3-4 and pN+ patients as those with the worst prognosis.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Aged -
- Aged, 80 and over -
- Carcinoma in Situ - mortality Carcinoma in Situ - pathology Carcinoma in Situ - surgery
- Cystectomy -
- Disease Progression -
- Female -
- Follow-Up Studies -
- Humans -
- Lymphatic Metastasis -
- Male -
- Middle Aged -
- Neoplasm Staging -
- Prognosis -
- Retrospective Studies -
- Risk Factors -
- Survival Rate - trends
- Time Factors -
- Urinary Bladder Neoplasms - mortality Urinary Bladder Neoplasms - pathology Urinary Bladder Neoplasms - surgery
- Find related publications in this database (Keywords)
- bladder cancer
- transitional cell carcinoma
- squamous cell carcinoma
- cancer-specific survival
- radical cystectomy
- prognostic factor
- TNM staging system, 2002