Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Ficarra, V; Dalpiaz, O; Alrabi, N; Novara, G; Galfano, A; Artibani, W.
Correlation between clinical and pathological staging in a series of radical cystectomies for bladder carcinoma.
BJU Int. 2005; 95(6):786-790
Doi: 10.1111/j.1464-410X.2005.05401.x
Web of Science
PubMed
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FullText_MUG
- Co-Autor*innen der Med Uni Graz
- Dalpiaz Orietta
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- Abstract:
- To analyse the rate of concordance between the clinical and pathological Tumour-Nodes-Metastasis staging systems in a homogeneous series of patients who had undergone radical cystectomy for locally advanced or recurrent multifocal superficial bladder carcinoma. The clinical data of 156 patients who had undergone radical cystectomy and bilateral iliaco-obturator lymphadenectomy for bladder cancer in our department were analysed retrospectively. The clinical stage of the primary tumour was carcinoma in situ in three patients (1.9%), cT1 in 67 (42.9%), cT2 in 70 (44.9%), cT3 in five (3.2%) and cT4 in nine (5.8%). Clinical lymph node involvement was detected in 19 patients (12.2%). The differences between clinical and pathological stages were statistically significant (P < 0.001), the concordance was moderate (kappa = 0.27, P < 0.001). Of the 70 patients with <= cT1, 40 (57%) were reconfirmed as having pathological stage <= T1; of the 70 with cT2, 16 (23%) had pT2 carcinoma. Of the 140 patients with clinically organ-confined (<= T2) neoplasms, 70 (50%) had been understaged after radical cystectomy. The clinical and pathological systems were statistically overlapping for locally advanced cases only. Pathological lymph node involvement was diagnosed in 45 patients (28.8%); this was foreseen with pelvic computed tomography in 19 (12%) only (P < 0.001). All patients designated cN+ were also pN+. These data confirm the high risk of clinical understaging of both local extension of the primary tumour and lymph node involvement.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Aged -
- Aged, 80 and over -
- Carcinoma, Squamous Cell - pathology Carcinoma, Squamous Cell - surgery
- Carcinoma, Transitional Cell - pathology Carcinoma, Transitional Cell - surgery
- Cystectomy - methods
- Female -
- Humans -
- Lymph Node Excision - methods
- Lymphatic Metastasis -
- Male -
- Middle Aged -
- Neoplasm Recurrence, Local - pathology Neoplasm Recurrence, Local - surgery
- Neoplasm Staging - methods
- Retrospective Studies -
- Risk Factors -
- Urinary Bladder Neoplasms - pathology Urinary Bladder Neoplasms - surgery
- Find related publications in this database (Keywords)
- bladder cancer
- TCC
- squamous cell carcinoma
- survival
- radical cystectomy
- staging
- TNM