Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
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SHR Neuro Krebs Kardio Lipid Stoffw Microb
Novara, G; De Marco, V; Dalpiaz, O; Galfano, A; Bouygues, V; Gardiman, M; Martignoni, G; Patard, JJ; Artibani, W; Ficarra, V.
Independent predictors of contralateral metachronous upper urinary tract transitional cell carcinoma after nephroureterectomy: multi-institutional dataset from three European centers.
Int J Urol. 2009; 16(2): 187-191.
Doi: 10.1111/j.1442-2042.2008.02201.x
Web of Science
PubMed
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- Co-Autor*innen der Med Uni Graz
- Dalpiaz Orietta
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- Abstract:
- To identify the variables predictive of contralateral metachronous upper urinary tract transitional cell carcinoma (UUT-TCC) after nephroureterectomy (NFU) for non-metastatic UUT-TCC. Clinical and pathological data of 234 patients who had undergone NFU for UUT-TCC from 1989 to 2005 in three European urological centers were retrospectively collected and analyzed. The median follow-up duration for the whole cohort was 34 months. Contralateral metachronous UUT-TCC was detected in 14 patients (6%). Three patients were treated by NFU, while seven patients underwent ureterectomy and reimplantation and four patients were treated by endoscopic resection plus bacillus Calmette-GuErin instillations within the UUT through a nephrostomic tube. On univariate analysis, a prior history of bladder TCC before NFU was the only factor predictive of the occurrence of contralateral UUT-TCC. Specifically, the 5-year probabilities of being free from contralateral UUT-TCC were 96.6% for the patients with de novo UUT-TCC, and 91.1% and 55.3% for those having non-muscle-invasive and muscle invasive bladder TCC before the UUT cancer, respectively. All survival differences were statistically significant (no history of bladder TCC vs history of non-muscle-invasive bladder TCC, log rank P value 0.015; history of non-muscle-invasive bladder TCC vs history of muscle-invasive bladder TCC, log rank P value 0.035). In our multicenter dataset of patients who had undergone NFU for UUT-TCC, contralateral metachronous UUT-TCC occurred in 6% of the patients. A prior history of bladder TCC before NFU was the only variable predictive of UUT recurrence at univariate analysis.
- Find related publications in this database (using NLM MeSH Indexing)
- Aged -
- Carcinoma, Transitional Cell - epidemiology Carcinoma, Transitional Cell - pathology Carcinoma, Transitional Cell - surgery
- Europe - epidemiology
- Female -
- Humans -
- Kidney - pathology
- Kidney Neoplasms - epidemiology Kidney Neoplasms - pathology Kidney Neoplasms - surgery
- Male -
- Middle Aged -
- Nephrectomy -
- Prognosis -
- Recurrence -
- Retrospective Studies -
- Ureter - pathology
- Ureteral Neoplasms - epidemiology Ureteral Neoplasms - pathology Ureteral Neoplasms - surgery
- Find related publications in this database (Keywords)
- bladder cancer
- nephroureterectomy
- upper urinary tract transitional cell carcinoma
- ureterectomy