Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Schellander, R; Donnerer, J.
Antidepressants: clinically relevant drug interactions to be considered.
Pharmacology. 2010; 86(4): 203-215.
Doi: 10.1159/000319744
Web of Science
PubMed
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- Führende Autor*innen der Med Uni Graz
- Donnerer Josef
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- Abstract:
- Drug interactions in clinical practice are common and have developed into an increasing challenge for the medical profession. Specifically antidepressant drugs (ADs), which are among the 5 most frequently prescribed drugs, are predestined for adverse drug interactions because of their multiple mechanisms of action and/or their influence on drug-metabolizing cytochrome P450 (CYP) enzymes. Although selective serotonin reuptake inhibitors (SSRIs) and other new-generation ADs have an overall improved safety profile, their potential for drug interactions is to be considered. A review of the current literature has been performed, and selected examples of clinically relevant interactions with ADs have been chosen. With regard to pharmacodynamic interactions, the serotonin syndrome, the risk of bleeding under SSRI therapy, and the corrected Q-T interval prolongation are discussed in this review. The inhibitory effects of new-generation ADs on CYP enzymes show great variability and might be relevant for prescription recommendations in elderly patients and in patients with polypharmacy. The CYP-enzyme-inducing effect of St. John's wort, a popular over-the-counter herbal drug, may lead to decreased plasma levels of CYP substrates. When comparing prescription data and observed adverse drug events, there is fortunately a safety gap between the number of potential drug-drug interactions and the number of clinically observed side effects due to drug-drug interactions.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Antidepressive Agents - adverse effects
- Cytochrome P-450 Enzyme System - metabolism
- Drug Interactions -
- Enzyme Induction - drug effects
- Enzyme Inhibitors - pharmacology
- Hemorrhage - chemically induced
- Humans -
- Long QT Syndrome - chemically induced
- Serotonin Syndrome - chemically induced
- Serotonin Uptake Inhibitors - adverse effects
- Find related publications in this database (Keywords)
- Antidepressant drugs
- Drug interactions
- Cytochrome P450
- Selective serotonin reuptake inhibitors