Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
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Robier, C; Neubauer, M; Sternad, H; Quehenberger, F; Rainer, F; Neumeister, P.
Evaluation of platelet function and pharmacological platelet inhibition in patients with myeloproliferative disorders using multiple electrode aggregometry.
THROMB RES. 2010; 126(3): 232-237.
Doi: 10.1016/j.thromres.2010.06.014
Web of Science
PubMed
FullText
FullText_MUG
- Führende Autor*innen der Med Uni Graz
- Robier Christoph
- Co-Autor*innen der Med Uni Graz
- Neumeister Peter
- Quehenberger Franz
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- Abstract:
- Background: The aim of this study was to describe platelet aggregation characteristics by multiple electrode aggregometry (MEA) and to evaluate MEA for its potential to detect platelet dysfunction and response to anti-aggregatory drugs in patients with myeloproliferative disorders (MPD). Methods: We compared the platelet response to arachidonic acid (ASPI test), adenosine diphosphate (ADP test) and thrombin receptor activating peptide (TRAP test) in hirudin-anticoagulated blood of 55 patients with polycythaemia vera and essential thrombocythaemia and 75 controls. Results: Comparing MPD patients and controls no statistically significant difference indicative of platelet dysfunction was found in MPD patients. Analysis of covariance revealed platelet- and leukocyte count as a significant influencing factor on MEA function. Furthermore we could demonstrate that ASA and clopidogrel treatment results in a statistically significant lower ASPI (Controls: p<0.0001, MPD: p<0.0001) and ADPtest value (MPD: p=0.00125) compared to untreated patients thereby validating the method for monitoring of anti-aggregatory therapy. Conclusion: In this study MEA was confirmed as a valid method for monitoring of ASA and clopidogrel treatment in patients with MPD and normal control subjects. The platelet and leukocyte count were identified as major influencing factors on MEA aggregation tests both in MPD patients and controls. No functional platelet abnormalities were detected in MPD patients. (C) 2010 Elsevier Ltd. All rights reserved.
- Find related publications in this database (using NLM MeSH Indexing)
- Adenosine Diphosphate - diagnostic use
- Adult -
- Aged -
- Arachidonic Acid - diagnostic use
- Aspirin - therapeutic use
- Aspirin -
- Case-Control Studies -
- Electrodes -
- Female -
- Humans -
- Linear Models -
- Male -
- Middle Aged -
- Peptides - diagnostic use
- Platelet Aggregation - drug effects
- Platelet Aggregation Inhibitors - therapeutic use
- Platelet Function Tests - instrumentation
- Polycythemia Vera - blood
- Predictive Value of Tests -
- Reproducibility of Results -
- Thrombocythemia, Essential - blood
- Thrombosis - blood
- Ticlopidine - analogs and derivatives
- Treatment Outcome -
- Young Adult -
- Find related publications in this database (Keywords)
- Aggregometry
- Platelet aggregation
- Multiplate
- Myeloproliferative disorders