Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Novacek, G; Weltermann, A; Sobala, A; Tilg, H; Petritsch, W; Reinisch, W; Mayer, A; Haas, T; Kaser, A; Feichtenschlager, T; Fuchssteiner, H; Knoflach, P; Vogelsang, H; Miehsler, W; Platzer, R; Tillinger, W; Jaritz, B; Schmid, A; Blaha, B; Dejaco, C; Eichinger, S.
Inflammatory bowel disease is a risk factor for recurrent venous thromboembolism.
Gastroenterology. 2010; 139(3):779-787
Doi: 10.1053/j.gastro.2010.05.026
Web of Science
PubMed
FullText
FullText_MUG
- Co-Autor*innen der Med Uni Graz
- Dejaco Christian
- Petritsch Wolfgang
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- Abstract:
- Patients with inflammatory bowel disease (IBD) are at increased risk of a first venous thromboembolism (VTE), yet their risk of recurrent VTE is unknown. We performed a cohort study to determine the risk for recurrent VTE among patients with IBD compared with subjects without IBD. We assessed 2811 patients with IBD for a history of VTE, recruited from outpatient clinics at 14 referral centers (June 2006-December 2008). Patients with VTE before a diagnosis of IBD or those not confirmed to have VTE, cancer, or a VTE other than deep vein thrombosis or pulmonary embolism, were excluded. Recurrence rates were compared with 1255 prospectively followed patients without IBD that had a first unprovoked VTE (not triggered by trauma, surgery, or pregnancy). The primary end point was symptomatic, objectively confirmed, recurrent VTE after discontinuation of anticoagulation therapy after a first VTE. Overall, of 116 IBD patients who had a history of first VTE, 86 were unprovoked. The probability of recurrence 5 years after discontinuation of anticoagulation therapy was higher among patients with IBD than patients without IBD (33.4%; 95% confidence interval [CI]: 21.8-45.0 vs 21.7%; 95% CI: 18.8-24.6; P = .01). After adjustment for potential confounders, IBD was an independent risk factor of recurrence (hazard ratio = 2.5; 95% CI: 1.4-4.2; P = .001). Patients with IBD are at an increased risk of recurrent VTE compared to patients without IBD. Copyright © 2010 AGA Institute. Published by Elsevier Inc. All rights reserved.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Anticoagulants - administration & dosage
- Anticoagulants -
- Case-Control Studies -
- Chi-Square Distribution -
- Drug Administration Schedule -
- Female -
- Gastrointestinal Agents - therapeutic use
- Humans -
- Inflammatory Bowel Diseases - complications Inflammatory Bowel Diseases - drug therapy
- Kaplan-Meier Estimate -
- Male -
- Middle Aged -
- Proportional Hazards Models -
- Prospective Studies -
- Pulmonary Embolism - diagnosis Pulmonary Embolism - drug therapy Pulmonary Embolism - etiology
- Recurrence -
- Retrospective Studies -
- Risk Assessment -
- Risk Factors -
- Time Factors -
- Treatment Outcome -
- Venous Thromboembolism - diagnosis Venous Thromboembolism - drug therapy Venous Thromboembolism - etiology
- Venous Thrombosis - diagnosis Venous Thrombosis - drug therapy Venous Thrombosis - etiology
- Find related publications in this database (Keywords)
- Crohn's Disease
- Ulcerative Colitis
- Active Disease
- Provoked Thrombosis