Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Moinfar, F.
Flat ductal intraepithelial neoplasia of the breast: evolution of Azzopardi's "clinging" concept.
Semin Diagn Pathol. 2010; 27(1):37-48
Doi: 10.1053/j.semdp.2009.12.005
Web of Science
PubMed
FullText
FullText_MUG
- Leading authors Med Uni Graz
- Moinfar Farid
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- Thirty years ago, John G. Azzopardi described a mainly cytologically defined atypical intraepithelial lesion of the breast, which he called "clinging carcinoma in situ," a variant of "ductal carcinoma in situ." The lesion was characterized by replacement of native epithelial cells by very few cell layers of mildly to severely atypical epithelial cells. Based on the degree of cytologic atypia, Azzopardi distinguished type 1 with highly atypical nuclei and type 2 with merely subtle cytologic (nuclear) atypia. Although this distinctive lesion remained widely unrecognized and/or ignored by many pathologists for a long period, several recent studies strongly suggest its neoplastic nature. The aim of this review is to focus on the "clinging" concept and its evolution after the first description. The diagnostic criteria, main diagnostic pitfalls, immunohistochemistry, molecular-genetic findings, and the relevance of this type of lesion for clinicians and histopathologists are discussed. Rational for adopting a more appropriate terminology and classification, namely flat ductal intraepithelial neoplasia are also discussed. It is concluded that the "clinging" or flat lesion represents one of the earliest morphologically recognizable neoplastic breast lesions. This lesion is important, if one tries to better understand the tumorigenesis of early precursor lesions of the breast. This type of breast lesion is an indicator for coexisting neoplastic lesions, such as low-grade ductal intraepithelial neoplasia (atypical ductal hyperplasia/low-grade ductal carcinoma in situ) and lobular intraepithelial neoplasia.
- Find related publications in this database (using NLM MeSH Indexing)
- Breast Neoplasms - genetics Breast Neoplasms - metabolism Breast Neoplasms - pathology
- Carcinoma, Intraductal, Noninfiltrating - genetics Carcinoma, Intraductal, Noninfiltrating - metabolism Carcinoma, Intraductal, Noninfiltrating - pathology
- Cell Nucleus - metabolism Cell Nucleus - pathology
- DNA, Neoplasm - analysis
- Diagnosis, Differential -
- Disease Progression -
- Female -
- Fibrocystic Breast Disease - diagnosis
- Humans -
- Loss of Heterozygosity -
- Precancerous Conditions - metabolism Precancerous Conditions - pathology
- Terminology as Topic -
- Tumor Markers, Biological - metabolism
- Find related publications in this database (Keywords)
- Clinging carcinoma in situ
- Flat ductal intraepithelial neoplasia
- Flat epithelial atypia
- Columnar cell lesions
- Early breast neoplasia