Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Herting, E; Speer, CP; Harms, K; Robertson, B; Curstedt, T; Halliday, HL; Compagnone, D; Gefeller, O; McClure, G; Reid, M.
Factors influencing morbidity and mortality in infants with severe respiratory distress syndrome treated with single or multiple doses of a natural porcine surfactant.
BIOL NEONATE. 1992; 61 Suppl 1(4): 26-30.
Doi: 10.1159/000243840
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- Co-Autor*innen der Med Uni Graz
- Haim Michaela
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- Abstract:
- In an international multicenter trial infants with clinical and radiological signs of severe RDS (age 2-15 h, birthweight 700-2,000 g, mechanical ventilation, FiO2 greater than or equal to 0.6, no complicating disease) were randomized to receive either a single dose (n = 176) or up to three subsequent doses (n = 167) of a natural porcine surfactant (Curosurf). Using a logistic regression model, the effects of therapy, birthweight, sex, hospital and other clinical factors on survival and various outcome parameters were evaluated. Mortality (13 vs. 21%, p less than 0.05) and the incidence of pneumothorax (9 vs. 18%, p less than 0.01) were significantly lower in the multiple-dose group. Low birthweight, hospital allocation, low Apgar score and initial disease severity were associated with an increased mortality. Low birthweight, hypothermia (admission temperature less than 36 degrees C) and acidosis (pH less than 7.25) prior to surfactant treatment could be identified as risk factors for the development of intracranial hemorrhage.
- Find related publications in this database (using NLM MeSH Indexing)
- Biological Products -
- Dose-Response Relationship, Drug -
- Female -
- Humans -
- Infant, Low Birth Weight -
- Infant, Newborn -
- Male -
- Morbidity -
- Phospholipids -
- Pneumothorax - etiology
- Pulmonary Surfactants - therapeutic use
- Regression Analysis - therapeutic use
- Respiratory Distress Syndrome, Newborn - complications
- Risk Factors - complications
- Find related publications in this database (Keywords)
- Respiratory Distress Syndrome
- Pulmonary Surfactants
- Infant
- Newborn