Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Mossböck, G; Weger, M; Faschinger, C; Zimmermann, C; Schmut, O; Renner, W; El-Shabrawi, Y.
Role of functional single nucleotide polymorphisms of MMP1, MMP2, and MMP9 in open angle glaucomas.
Mol Vis. 2010; 16(12): 1764-1770.
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- Führende Autor*innen der Med Uni Graz
- Mossböck Georg
- Co-Autor*innen der Med Uni Graz
- El-Shabrawi Yosuf
- Faschinger Christoph
- Renner Wilfried
- Schmut Otto
- Weger Martin
- Zimmermann-Roth Christina
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- Abstract:
- Purpose: Matrix metalloproteinases (MMPs) play an essential role in the turnover of the extracellular matrix and cellular behavior. MMP1, MMP2, and MMP9 have previously been implicated in the pathogenesis of primary open angle glaucoma (POAG) and open angle glaucoma secondary to exfoliation syndrome (XFG), respectively. Functional gene polymorphisms of these MMPs such as MMP1 -1607 1G/2G (rs1799750), MMP2 -1306 C/T (rs243865), MMP2 -1575 G/A (rs243866), and MMP9 Q279R (rs17576) are thus plausible candidates as risk factors for open angle glaucomas. The purpose of the present study was to investigate hypothesized associations between these polymorphisms and the presence of POAG and XFG in a Caucasian population. Methods: The present case-control study included 322 patients with POAG, 202 patients with XFG, and 248 control subjects. Genotyping of polymorphisms was done using polymerase chain reaction. Results: No significant differences in either genotype distributions or allelic frequencies of MMP1 -1607 1G/2G, MMP2 -1306 C/T, MMP2 -1575 G/A, and MMP9 Q279R were found between patients with POAG and control subjects and patients with XFG and control subjects, respectively (p>0.05). The presence of POAG or XFG was not predicted by any of the investigated polymorphisms. Conclusions: Our data suggest that the MMP1 -1607 1G/2G, MMP2 -1306 C/T, MMP2 -1575 G/A, and MMP9 Q279R polymorphisms themselves are unlikely major risk factors among Caucasian patients with either POAG or XFG.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Aged -
- Aged, 80 and over -
- Case-Control Studies -
- Exfoliation Syndrome - enzymology Exfoliation Syndrome - genetics
- Female -
- Gene Frequency - genetics
- Genotype -
- Glaucoma, Open-Angle - enzymology Glaucoma, Open-Angle - genetics
- Humans -
- Logistic Models -
- Male -
- Matrix Metalloproteinase 1 - genetics
- Matrix Metalloproteinase 2 - genetics
- Matrix Metalloproteinase 9 - genetics
- Matrix Metalloproteinases - genetics
- Middle Aged -
- Polymorphism, Single Nucleotide - genetics