Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Hafner, F; Seinost, G; Gary, T; Froehlich, H; Pilger, E; Brodmann, M.
Are flow-mediated vasodilatation and intima-media thickness of the brachial artery associated with restenosis after endovascular treatment of peripheral arterial occlusive disease?
Eur Radiol. 2010; 20(10): 2533-2540.
Doi: 10.1007/s00330-010-1801-z
Web of Science
PubMed
FullText
FullText_MUG
- Leading authors Med Uni Graz
- Hafner Franz
- Co-authors Med Uni Graz
- Brodmann Marianne
- Fröhlich Harald
- Gary Thomas
- Pilger Ernst
- Seinost Gerald
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- Restenosis after percutaneous angioplasty of peripheral arteries is still an unsolved matter. Previous studies reported an association between flow-mediated dilatation (FMD), a marker of endothelial dysfunction, and restenosis after coronary angioplasty. This study evaluates the influence of FMD and brachial intima-media thickness (B-IMT) on restenosis after angioplasty of peripheral arteries. One hundred and eighty-four patients (124 male) with claudication related to peripheral arterial disease participated in this trial. FMD and B-IMT were assessed before endovascular revascularisation. In a 12-month follow-up duplex ultrasound examinations were performed to detect restenosis. Finally 128 patients (91male, 37 female) were eligible for statistical analysis. Restenosis was found in 54 patients (42.2%). Mean FMD was 3.53 +/- 3.56%, with no difference between the patients with restenosis (3.55 +/- 3.64%) and those without (3.52 +/- 3.48%; p = 0.716). B-IMT had a mean value of 0.326 +/- 0.134 mm. B-IMT significantly differed between the patients with restenosis (0.326 +/- 0.134 mm) and those without (0.256 +/- 0.133 mm; p = 0.007). We confirmed that a B-IMT over 0.21 mm was an independent risk factor for restenosis [OR 2.9 (1.3-6.3)]. Endothelial dysfunction is not associated with restenosis. Conversely patients with enlarged B-IMT are at risk of restenosis after angioplasty of peripheral arteries.
- Find related publications in this database (using NLM MeSH Indexing)
- Angioplasty - methods
- Angioplasty, Balloon - methods
- Brachial Artery - pathology
- Endothelium, Vascular - pathology
- Female -
- Follow-Up Studies -
- Humans -
- Male -
- Odds Ratio -
- Peripheral Vascular Diseases - pathology
- Prospective Studies -
- Risk -
- Risk Factors -
- Tunica Intima - pathology
- Tunica Media - pathology
- Vasodilation -
- Find related publications in this database (Keywords)
- Restenosis
- Flow mediated dilatation
- Endothelial dysfunction
- Intima-media thickness
- Peripheral arterial disease