Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Schuster, C; Kränke, B; Aberer, E; Arbab, E; Sturm, G; Aberer, W.
Schnitzler syndrome: response to anakinra in two cases and a review of the literature.
Int J Dermatol. 2009; 48(11): 1190-1194.
Doi: 10.1111/j.1365-4632.2009.04151.x
(- Case Report)
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- Führende Autor*innen der Med Uni Graz
- Schuster Christian Josef
- Co-Autor*innen der Med Uni Graz
- Aberer Elisabeth
- Aberer Werner
- Arbab Emad
- Kränke Birger
- Sturm Gunter
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- Abstract:
- BACKGROUND: Schnitzler syndrome is a rare disease characterized by a chronic urticarial eruption and monoclonal gammopathy, as well as clinical and laboratory signs of inflammation. The pathophysiology is still unknown, although various autoantibody-mediated mechanisms have been described. Complete remission of symptoms has been reported recently in patients with Schnitzler syndrome treated with anakinra, an interleukin-1 receptor antagonist. METHODS: Two patients with Schnitzler syndrome treated with anakinra therapy are presented. RESULTS: We report two cases of nearly complete remission of symptoms in Schnitzler syndrome after the initiation of anakinra therapy, and the first observation of a relapse under continuous daily anakinra therapy. A review of the published literature on the treatment of Schnitzler syndrome with anakinra is presented. CONCLUSIONS: Based on published data, monotherapy with anakinra is currently the most promising treatment for Schnitzler syndrome, because it is able to induce complete remission of symptoms.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Antirheumatic Agents - therapeutic use
- Female -
- Humans -
- Interleukin 1 Receptor Antagonist Protein - therapeutic use
- Male -
- Middle Aged -
- Remission Induction -
- Schnitzler Syndrome - drug therapy
- Treatment Outcome -