Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Pilz, S; Tomaschitz, A; Drechsler, C; Zittermann, A; Dekker, JM; März, W.
Vitamin d supplementation: a promising approach for the prevention and treatment of strokes.
Curr Drug Targets. 2011; 12(1): 88-96.
Doi: 10.2174/138945011793591563
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- Führende Autor*innen der Med Uni Graz
- Pilz Stefan
- Co-Autor*innen der Med Uni Graz
- März Winfried
- Tomaschitz Andreas
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- Abstract:
- Vitamin D deficiency is highly prevalent due to lifestyle and environmental factors which limit sunlight induced vitamin D production in the skin. This "pandemic" of vitamin D deficiency is of concern because low levels of 25-hydroxyvitamin D (25[OH]D) have been associated with cardiovascular, musculoskeletal, infectious, autoimmune and malignant diseases. Epidemiological studies have largely but not consistently shown that vitamin D deficiency is a risk factor for strokes. This is supported by associations of low 25(OH)D levels with cerebrovascular risk factors, in particular with arterial hypertension. Vitamin D has also been shown to exert neuroprotective, neuromuscular and osteoprotective effects which may reduce cognitive and functional impairments in poststroke patients. Hence, the current literature favours the notion that vitamin D supplementation is a promising approach for the prevention and treatment of strokes but accurate data from interventional studies are missing. Randomized controlled trials are therefore urgently needed to evaluate whether vitamin D supplementation reduces the incidence of strokes and improves the outcome of poststroke patients. We do, however, believe that currently published data on the multiple health benefits of vitamin D and the easy safe and inexpensive way by which it can be supplemented already argue for the prevention and treatment of vitamin D deficiency in order to reduce stroke associated morbidity and mortality.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Dietary Supplements -
- Humans -
- Risk Factors -
- Stroke - drug therapy
- Vitamin D - analogs and derivatives
- Vitamin D Deficiency - epidemiology
- Find related publications in this database (Keywords)
- Cardiovascular
- cerebrovascular
- cognitive
- neuromuscular
- vitamin D
- stroke