Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
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SHR Neuro Krebs Kardio Lipid Stoffw Microb
Walder, B; Fontao, E; Totsch, M; Morel, DR.
Time and tidal volume-dependent ventilator-induced lung injury in healthy rats
EUR J ANAESTH. 2005; 22(10): 786-794.
Doi: 10.1017/S0265021505001304
Web of Science
PubMed
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- Co-Autor*innen der Med Uni Graz
- Tötsch Martin
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- Abstract:
- BACKGROUND AND OBJECTIVE: We evaluated the effect of duration of mechanical ventilation with different tidal volumes (VT) on ventilator-induced lung injury in healthy rats. METHODS: Anaesthetized rats were ventilated with VT between 9 and 45 mL kg[-1] for 1 or 7 h with a positive end-expiratory pressure of 2.5 cmH2O. RESULTS: After 1 h, rats ventilated even with the highest applied VT (36 and 45 mL kg[minus sign]1, resulting in average peak airway pressures of 30 +/-3 and 37 +/- 4 cmH2O), had no detectable alterations in dynamic or static lung mechanics, gas exchange or pulmonary permeability, but a moderate degree of lung inflammation (neutrophil accumulation in broncho-alveolar lavage) observed in all groups. In contrast, after 3 h of ventilation, rats ventilated with the highest VT (36 and 45 mL kg[minus sign]1) died from progressive circulatory failure and high-permeability pulmonary oedema, manifested by hypoxaemia, an increased alveolar-arterial protein concentration ratio and a reduced static lung compliance (mortality rate at 7 h, 62.5% and 100%). Animals with lower VT all survived and presented no changes in the measured variables. CONCLUSION: These results in normal rats demonstrate the preponderant effect of the duration (>3 h) of 'aggressive' ventilation and the cut-off value of the level of VT applied (>27 mL kg[minus sign]1).
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Blood Gas Analysis -
- Bronchoalveolar Lavage Fluid - cytology
- Capillary Leak Syndrome - physiopathology
- Data Interpretation, Statistical -
- Lung - pathology
- Lung Compliance - physiology
- Lung Injury -
- Neutrophils - physiology
- Oxygen - blood
- Proteins - metabolism
- Pulmonary Alveoli - metabolism
- Pulmonary Gas Exchange - physiology
- Rats -
- Rats, Sprague-Dawley -
- Respiration, Artificial - adverse effects
- Respiratory Mechanics - physiology
- Tidal Volume - physiology
- Find related publications in this database (Keywords)
- positive pressure respiration, tidal volume, airway pressure
- lung compliance
- model, animal, rat
- broncho-alveolar lavage fluid, protein, neutrophils
- respiratory distress syndrome