Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Szarvas, T; Becker, M; vom Dorp, F; Gethmann, C; Tötsch, M; Bánkfalvi, A; Schmid, KW; Romics, I; Rübben, H; Ergün, S.
Matrix metalloproteinase-7 as a marker of metastasis and predictor of poor survival in bladder cancer.
Cancer Sci. 2010; 101(5):1300-1308
Doi: 10.1111/j.1349-7006.2010.01506.x
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- Co-Autor*innen der Med Uni Graz
- Tötsch Martin
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- Abstract:
- Matrix metalloproteinases (MMPs) play an important role in tumor progression and metastasis. Here, we investigated the prognostic relevance of MMP-7 in urinary bladder cancer. MMP-7 gene expression was measured in tissue samples of 101 patients using quantitative real-time PCR. Circulating MMP-7 serum levels of 98 individuals (79 patients and 19 controls) were analyzed by enzyme-linked immunosorbent assay. The results were compared with the clinical follow-up data, performing Kaplan-Meier log-rank test as well as univariate and multivariate Cox analysis. In representative cases, immunohistochemical analysis for MMP-7 was performed. We detected significantly elevated MMP-7 levels both in tissue and serum samples of patients with metastatic disease (P = 0.001 and P = 0.002). Multivariate analysis revealed that high MMP-7 tissue expression and serum concentration are stage- and grade-independent predictors of both metastasis-free (hazard ratio [HR] = 3.80, 95% confidence interval [CI], 1.29-11.23, P = 0.016, and HR = 2.53, 95% CI, 1.01-6.37, P = 0.048) and disease-specific survival (HR = 1.89, 95% CI, 1.00-3.55, P = 0.050 and HR = 1.95, 95% CI, 1.03-3.71, P = 0.041). Based on these findings, we conclude that MMP-7 is a promising marker to detect present and to predict future metastasis. Serum MMP-7 analysis provides information about the risk of metastasis before surgery which could help to optimize therapeutic procedures. Furthermore, high MMP-7 tissue and/or serum levels could identify patients most likely to benefit from early adjuvant chemotherapy.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Aged -
- Female -
- Humans -
- Immunohistochemistry -
- Male -
- Matrix Metalloproteinase 7 - analysis Matrix Metalloproteinase 7 - blood Matrix Metalloproteinase 7 - genetics
- Middle Aged -
- Multivariate Analysis -
- Neoplasm Metastasis -
- Tumor Markers, Biological - analysis
- Urinary Bladder Neoplasms - mortality Urinary Bladder Neoplasms - pathology