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SHR Neuro Cancer Cardio Lipid Metab Microb

Feilchenfeldt, J; Bründler, MA; Soravia, C; Tötsch, M; Meier, CA.
Peroxisome proliferator-activated receptors (PPARs) and associated transcription factors in colon cancer: reduced expression of PPARgamma-coactivator 1 (PGC-1).
Cancer Lett. 2004; 203(1):25-33 Doi: 10.1016/j.canlet.2003.08.024
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Co-authors Med Uni Graz: Tötsch Martin
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Abstract:: Peroxisome proliferator-activated receptors (PPARs) alpha,beta/delta and gamma are fatty acid sensitive transcription factors that have been implicated in colorectal cancer. To better understand their role, we studied the expression levels of all PPAR-isoforms and transcriptional partners such as the retinoid X receptor alpha (RXRalpha) and PPARgamma-coactivator-1 (PGC-1) by means of real-time PCR in 17 patients with colon cancer. While a heterogeneous pattern was observed for the expression level of the PPAR-isoforms alpha,beta/delta and gamma, the coactivator PGC-1 was significantly decreased in 15 of 17 tumors. Taken together our data suggest that the transcriptional activity of PPARgamma may not only be decreased by mutation but also by downregulation of the coactivator PGC-1 of PPARgamma.
Find related publications in this database (using NLM MeSH Indexing): Adult -; Aged -; Colonic Neoplasms - genetics Colonic Neoplasms - metabolism; Down-Regulation -; Female -; Humans -; Male -; Middle Aged -; Mutation -; Protein Isoforms - metabolism; Receptors, Cytoplasmic and Nuclear - genetics Receptors, Cytoplasmic and Nuclear - metabolism; Receptors, Retinoic Acid - metabolism; Retinoid X Receptors -; Reverse Transcriptase Polymerase Chain Reaction -; Transcription Factors - genetics Transcription Factors - metabolism
Find related publications in this database (Keywords): peroxisome proliferator-activated receptor; 9-cis retinoic acid receptor; PPAR gamma-coactivator-1; colorectal cancer