Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Meister, B; Tötsch, M; Mayr, A; Widschwendter, M; Huter, O; Sperl, W.
Identification of CD34+ cord blood cells and their subpopulations in preterm and term neonates using three-color flow cytometry.
Biol Neonate. 1994; 66(5): 272-279.
Doi: 10.1159/000244117
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PubMed
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- Co-Autor*innen der Med Uni Graz
- Tötsch Martin
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- Abstract:
- Three-color flow cytometry was used to identify CD34+ cord blood (CB) hematopoietic progenitors of preterm (n = 13) and term (n = 18) neonates. The frequency of CD34+ CB cells gated on the lymphocyte fraction in term neonates is about half the frequency of preterm neonates (mean 1.84 +/- 0.8 vs. 3.49 +/- 1.8, p < 0.005). The difference of absolute CD34+ cells between the 2 groups did not reach statistical significance (premature 169 +/- 161 vs. mature 108 +/- 62.6 x 10(6) cells/l). The proportion of myeloid lineage-committed CD34+ cells coexpressing the CD33 antigen in preterm neonates does not significantly differ from that found in term neonates. However, in preterm neonates a higher fraction of erythroid lineage-committed CD34+ cells coexpresses the CD71 antigen as compared with term neonates (mean 28.7 +/- 14.1 vs. 11.4 +/- 5.7, p < 0.001). The positive correlation between gestational age and the ratio of myeloid/erythroid lineage-specific progenitor cells (r = 0.61, n = 31, p < 0.0005) suggests gestational changes in lineage commitment of CD34+ cells.
- Find related publications in this database (using NLM MeSH Indexing)
- Antigens, CD - blood
- Antigens, CD34 -
- Antigens, Differentiation, B-Lymphocyte - blood
- Antigens, Differentiation, Myelomonocytic - blood
- Erythrocyte Count -
- Erythroid Precursor Cells - cytology Erythroid Precursor Cells - immunology
- Fetal Blood - cytology
- Flow Cytometry - methods
- Granulocytes - cytology Granulocytes - immunology
- HLA-DR Antigens - blood
- Hematopoietic Stem Cells - immunology
- Humans -
- Infant, Newborn -
- Infant, Premature - blood
- Leukocyte Count -
- Lymphocyte Count -
- Lymphocyte Subsets - cytology Lymphocyte Subsets - immunology
- Receptors, Transferrin -
- Find related publications in this database (Keywords)
- PROGENITOR CELLS
- CD34 ANTIGEN
- HEMATOPOIESIS, FETAL
- FLUORESCENT ACTIVATED CELL SORTER