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Ofner, D; Hittmair, A; Marth, C; Tötsch, M; Daxenbichler, G; Margreiter, R; Böcker, W; Schmid, KW.
Relationship between quantity of silver stained nucleolar organizer region associated proteins (Ag-NORs) and growth rate suppression of breast cancer cell lines after interferon-gamma and 4-hydroxy-tamoxifen treatment.
Virchows Arch B Cell Pathol Incl Mol Pathol. 1993; 63(6):359-363 Doi: 10.1007/BF02899284
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Co-authors Med Uni Graz: Tötsch Martin
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Abstract:: The correlation between the silver-stained nucleolar organizer region associated proteins (Ag-NORs) and the growth rate suppression (GRS) of ten established breast cancer cell lines which were treated with 4-hydroxy-tamoxifen (OHT) and interferon-gamma (g-IFN), respectively, was investigated by means of automated image analysis. Previous studies have shown a statistically significant relationship between the Ag-NOR quantity and the population doubling time (PDT) of these cell clones. The results of the present study showed a highly significant correlation between the GRS and the Ag-NOR quantity in estrogen receptor (ER) positive tumour cell lines after OHT treatment (P < 0.001) whereas no strict correlation of these parameters could be demonstrated after g-IFN treatment in both ER positive and negative cell lines. Our results suggest a different behaviour of NOR-proteins in breast cancer cell lines if treated either with g-IFN or OHT, probably reflecting the different mechanism of cell suppression mediated by OHT and g-IFN. It is concluded that quantitative assessment of Ag-NORs is not as suitable for the determination of the GRS as it is for the determination of cell duplication rates obtained on untreated tumour cell lines.
Find related publications in this database (using NLM MeSH Indexing): Breast Neoplasms - chemistry Breast Neoplasms - pathology; Cell Division - drug effects; Humans -; Interferon-gamma - pharmacology; Nuclear Proteins - analysis; Nucleolus Organizer Region - chemistry; Receptors, Estrogen - analysis; Silver Staining -; Tamoxifen - analogs and derivatives Tamoxifen - pharmacology; Tumor Cells, Cultured -
Find related publications in this database (Keywords): NUCLEOLAR ORGANIZER REGION ASSOCIATED PROTEINS; IMAGE ANALYSIS; BREAST CANCER; TUMOR CELL LINE; 4-HYDROXY-TAMOXIFEN; INTERFERON-GAMMA