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Selected Publication:
Ofner, D; Hittmair, A; Marth, C; Ofner, C; Tötsch, M; Daxenbichler, G; Mikuz, G; Margreiter, R; Schmid, KW.
Relationship between quantity of silver stained nucleolar organizer regions associated proteins (Ag-NORs) and population doubling time in ten breast cancer cell lines.
Pathol Res Pract. 1992; 188(6):742-746
Doi: 10.1016/S0344-0338(11)80171-8
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- Co-authors Med Uni Graz
- Tötsch Martin
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- Abstract:
- Using a one-step silver staining technique ten human breast cancer cell lines were investigated, determining by means of automated image analysis the mean area of Ag-NORs per nucleus, the total number of Ag-NORs, and the so-called "scattered" and "clustered" Ag-NORs. These parameters were statistically correlated with the population doubling time (PDT) of the various carcinoma cell lines of this series. Our results show that the mean area of Ag-NORs per nucleus (p less than 0.001) is highly significantly correlated to the PDT, whereas all other parameters were less or not significant. It is concluded that the assessment of the area of Ag-NORs by automated image analysis is a simple and reliable method for the determination of cell duplication rates.
- Find related publications in this database (using NLM MeSH Indexing)
- Breast Neoplasms - chemistry
- Cell Division - physiology
- Female -
- Humans -
- Image Processing, Computer-Assisted -
- Nuclear Proteins - analysis
- Nucleolus Organizer Region - chemistry
- Silver Staining -
- Time Factors -
- Tumor Cells, Cultured -
- Find related publications in this database (Keywords)
- NUCLEOLAR ORGANIZER REGIONS (AG-NORS)
- IMAGE ANALYSIS SYSTEM
- BREAST CANCER
- CELL LINE
- POPULATION DOUBLING TIME