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Selected Publication:
Tötsch, M; Müller, LC; Hittmair, A; Ofner, D; Gibbs, AR; Schmid, KW.
Immunohistochemical demonstration of chromogranins A and B in neuroendocrine tumors of the lung.
Hum Pathol. 1992; 23(3):312-316
Doi: 10.1016/0046-8177(92)90113-H
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- Leading authors Med Uni Graz
- Tötsch Martin
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- Abstract:
- Fifty neuroendocrine tumors of the lung (16 carcinoids, two atypical carcinoids/well-differentiated neuroendocrine carcinomas [WDNCs], 13 neuroendocrine carcinomas of intermediate cell type [SCNCs], and 19 neuroendocrine carcinomas of small cell type [SCNs]) were immunohistochemically investigated with antibodies against chromogranins A and B. All carcinoids and WDNCs were positive for both chromogranins A and B, whereas in cases of ICNC and SCNC both markers were only expressed in six and five cases, respectively. One ICNC was only positive for chromogranin A. In cases of SCNC five tumors were exclusively positive for chromogranin A and six were positive only for chromogranin B. Chromogranins are therefore excellent markers for the immunohistochemical demonstration of carcinoids and WDNCs. It may be speculated that expression of chromogranins in cases of ICNC and SCNC represents a higher degree of differentiation in these tumors.
- Find related publications in this database (using NLM MeSH Indexing)
- Carcinoid Tumor - chemistry Carcinoid Tumor - pathology
- Chromogranin A -
- Chromogranins - analysis
- Humans -
- Immunoenzyme Techniques -
- Lung Neoplasms - chemistry Lung Neoplasms - pathology
- Neoplasms, Nerve Tissue - chemistry Neoplasms, Nerve Tissue - pathology
- Find related publications in this database (Keywords)
- NEUROENDOCRINE TUMORS
- LUNG TUMORS
- LUNG CARCINOIDS
- SMALL CELL CARCINOMA
- IMMUNOHISTOCHEMISTRY
- CHROMOGRANIN-A, CHROMOGRANIN-B