Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Sandbichler, P; Erhart, R; Herbst, P; Schmid, T; Vogel, W; Thaler, W; Tötsch, M; Klima, G; Margreiter, R.
Simultaneous transplantation of isolated hepatocytes reduces rejection of small bowel allografts and improves survival in the rat.
Eur Surg Res. 1996; 28(3):222-226
Doi: 10.1159/000129460
Web of Science
PubMed
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- Co-Autor*innen der Med Uni Graz
- Tötsch Martin
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- Abstract:
- Hepatocytes transplanted some days prior to vascularized allografts were shown to have the potential to prolong allograft survival in the rat. In the present study, hepatocytes and small bowel allografts were transplanted simultaneously in a Lewis (donor)-Brown Norway (recipient) rat model. 8-15 x 10(6) liver cells were injected into the spleen of small bowel recipients. The administration of at least 10 mg cyclosporine A (CyA)/kg over 3 days was necessary to prevent early rejection of hepatocytes. In groups simultaneously receiving hepatocytes, small bowel grafts and 10 mg CyA/kg over 3 days, a significant mitigation of rejection and a prolongation of survival was achieved, compared to groups receiving solely small bowel grafts and 10 mg CyA/kg over 3 days. We conclude that simultaneously transplanted hepatocytes exert a protective effect on a grafted organ from the same donor, provided that early rejection of hepatocytes is prevented by sufficient immunosuppression.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Cell Separation -
- Cell Transplantation -
- Graft Rejection - mortality Graft Rejection - pathology Graft Rejection - prevention and control
- Intestine, Small - transplantation
- Liver - cytology
- Male -
- Necrosis -
- Rats -
- Rats, Inbred Lew -
- Survival Analysis -
- Transplantation, Homologous -
- Find related publications in this database (Keywords)
- small bowel
- hepatocytes
- transplantation
- rat