Medizinische Universität Graz - Research portal
Selected Publication:
Larcher, C; Julen, N; Prodinger, WM; Tötsch, M; Gürtler, L; Dierich, MP.
Reduced CD21 (CR2) and CD54 (ICAM-1) expression in MT2 cells with HIV-1 or HIV-2 strains.
Immunol Lett. 1995; 46(1-2):31-36
Doi: 10.1016/0165-2478(95)00015-W
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- Co-authors Med Uni Graz
- Tötsch Martin
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- Abstract:
- Alterations in the expression of cell-surface receptors have been reported in HIV-infected cells for CD4, CD25 (IL-2 receptor), CD2, CD3 and CD8 and CD26. In the present study we provide evidence that CD21 is down-regulated in the human T-lymphoblastoid cell line MT2 after infection with HIV-1 and -2 isolates. The same effect was observed with ICAM-1 (CD54). CD21 expression was monitored by means of fluorescence intensity, its functional ability to bind to C3d and by quantitative measurement of CD21-antigen in supernatants and cell lysates using an immunoassay. In addition, the decrease of CD21 and ICAM-1-specific mRNA suggests a mechanism at a transcriptional level. Our data suggest that HIV might have a direct influence on the receptor expression.
- Find related publications in this database (using NLM MeSH Indexing)
- Cell Line, Transformed -
- Down-Regulation - immunology
- HIV-1 - immunology
- HIV-2 - immunology
- Humans -
- Intercellular Adhesion Molecule-1 - genetics Intercellular Adhesion Molecule-1 - metabolism
- RNA, Messenger - analysis
- Receptors, Complement 3d - genetics Receptors, Complement 3d - metabolism
- T-Lymphocytes - immunology T-Lymphocytes - virology
- Find related publications in this database (Keywords)
- CR-2
- ICSM-1
- HIV-1
- HIV-2
- MT2