Medizinische Universität Graz - Research portal
Selected Publication:
Tötsch, M; Padberg, BC; Schröder, S; Ofner, D; Böcker, W; Fischer-Colbrie, R; Schmid, KW.
Secretoneurin in bronchopulmonary carcinoids--immunohistochemical comparison with chromogranins A and B and secretogranin II.
Histopathology. 1995; 26(4):357-361
Doi: 10.1111/j.1365-2559.1995.tb00198.x
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- Leading authors Med Uni Graz
- Tötsch Martin
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- Abstract:
- Ninety-nine classical and 11 atypical bronchopulmonary carcinoids were investigated immunohistochemically with an antibody against secretoneurin, a peptide proteolytically processed from secretogranin II (chromogranin C), as well as antibodies against chromogranin A and B and secretogranin II. Secretoneurin was immunolocalized in 86 tumours (78 classical and eight atypical carcinoids); secretogranin II was found in the same tumours in a similar distribution, whereas chromogranin A was present in all 100 and chromogranin B in 106 tumours investigated. Bronchopulmonary carcinoids are usually not associated with clinically or biochemically distinct syndromes. Although we found bronchial carcinoids with different immunohistochemical chromogranins/secretogranin patterns, no correlation with the biological behaviour of these tumours could be demonstrated.
- Find related publications in this database (using NLM MeSH Indexing)
- Carcinoid Tumor - chemistry
- Chromogranin A -
- Chromogranins - analysis
- Humans -
- Immunohistochemistry -
- Lung Neoplasms - chemistry
- Neuropeptides - analysis
- Proteins - analysis
- Secretogranin II -
- Find related publications in this database (Keywords)
- CARCINOID
- LUNG
- CHROMOGRANIN A
- CHROMOGRANIN B
- SECRETOGRANIN II
- SECRETONEURIN
- IMMUNOHISTOCHEMISTRY