Medizinische Universität Graz - Research portal
Selected Publication:
Schmid, KW; Schröder, S; Dockhorn-Dworniczak, B; Kirchmair, R; Tötsch, M; Böcker, W; Fischer-Colbrie, R.
Immunohistochemical demonstration of chromogranin A, chromogranin B, and secretogranin II in extra-adrenal paragangliomas.
Mod Pathol. 1994; 7(3):347-353
Web of Science
PubMed
- Co-authors Med Uni Graz
- Tötsch Martin
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- Abstract:
- Twelve sympathetic and 14 parasympathetic extra-adrenal paragangliomas were investigated immunohistochemically with antibodies against chromogranin A, chromogranin B, and secretogranin II. In sympathetic paragangliomas chromogranin A was found in 12/12 and chromogranin B in 11/12 tumors in almost all chief cells (the remaining tumor was focally chromogranin B positive), whereas secretogranin II was immunolocalized in the majority of chief cells in 5/12, in a focal distribution in 3/12, and only in a few scattered tumor cells in 3/12 cases. One case showed no secretogranin II immunoreactivity. In parasympathetic paragangliomas both chromogranin B and secretogranin II immunoreactivity was demonstrated in the majority of chief cells of all 14 tumors investigated. Chromogranin A showed a strong immunostaining in 2/14 cases; in 12 tumors chromogranin A was found in only a few chief cells or was completely absent. It is concluded that sympathetic and parasympathetic paragangliomas show a divergent expression of chromogranins/secretogranins that apparently reflects the different histogenetic origins of these tumors.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent -
- Adult -
- Aged -
- Aged, 80 and over -
- Chromogranin A -
- Chromogranin B -
- Chromogranins - analysis
- Female -
- Humans -
- Immunoenzyme Techniques -
- Male -
- Middle Aged -
- Nerve Tissue Proteins - analysis
- Nervous System Neoplasms - chemistry Nervous System Neoplasms - pathology
- Paraganglioma, Extra-Adrenal - chemistry Paraganglioma, Extra-Adrenal - pathology
- Parasympathetic Nervous System - chemistry Parasympathetic Nervous System - pathology
- Proteins - analysis
- Sympathetic Nervous System - chemistry Sympathetic Nervous System - pathology
- Tumor Markers, Biological -
- Find related publications in this database (Keywords)
- CHROMOGRANIN
- SECRETOGRANIN
- SECRETONEURIN
- EXTRAADRENAL PARAGANGLIOMA
- IMMUNOHISTOCHEMISTRY