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Selected Publication:
Schmid, KW; Hittmair, A; Ladurner, D; Sandbichler, P; Gasser, R; Tötsch, M.
Chromogranin A and B in parathyroid tissue of cases of primary hyperparathyroidism: an immunohistochemical study.
Virchows Arch A Pathol Anat Histopathol. 1991; 418(4):295-299
Doi: 10.1007/BF01600157
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- Co-authors Med Uni Graz
- Tötsch Martin
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- Abstract:
- Routinely processed parathyroid tissues from 26 cases with primary hyperparathyroidism (19 adenomas, 7 multiglandular hyperplasia) and 8 normal human parathyroid glands were investigated with antibodies against chromogranin A and B and parathyroid hormone (PTH). Normal parathyroids were immunohistochemically positive for PTH and chromogranin A but negative for chromogranin B. Hyperplastic glands showed a focal staining for PTH and chromogranin A without correlation of the staining pattern on serial sections. Adenomas were either uniformly positive for both PTH and chromogranin A or showed a staining pattern similar to that seen in hyperplastic glands. Focal chromogranin B positivity (less than 10% of cells) was found in 3 cases (1 hyperplastic gland and 2 cases of parathyroid adenoma with an immunohistochemical staining pattern similar to hyperplastic glands). Our immunohistochemical results may support previously published findings that most parathyroid adenomas are monoclonal neoplasms whereas hyperplastic glands are of polyclonal origin.
- Find related publications in this database (using NLM MeSH Indexing)
- Adenoma - metabolism Adenoma - pathology
- Adult -
- Aged -
- Aged, 80 and over -
- Antibodies, Monoclonal - diagnostic use Antibodies, Monoclonal - immunology
- Chromogranin A -
- Chromogranins - immunology Chromogranins - metabolism
- Female -
- Humans -
- Hyperparathyroidism - metabolism Hyperparathyroidism - pathology
- Immunohistochemistry - methods
- Male -
- Middle Aged -
- Parathyroid Glands - metabolism Parathyroid Glands - pathology
- Parathyroid Hormone - immunology Parathyroid Hormone - metabolism
- Parathyroid Neoplasms - metabolism Parathyroid Neoplasms - pathology
- Find related publications in this database (Keywords)
- PARATHYROID GLAND
- PRIMARY HYPERPARATHYROIDISM
- IMMUNOHISTOCHEMISTRY
- CHROMOGRANIN-A
- CHROMOGRANIN-B