Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Fritsch, P; Kleber, M; Rosenkranz, A; Fritsch, M; Muntean, W; Mangge, H; Reinehr, T.
Haemostatic alterations in overweight children: associations between metabolic syndrome, thrombin generation, and fibrinogen levels.
Atherosclerosis. 2010; 212(2):650-655
Doi: 10.1016/j.atherosclerosis.2010.06.028
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- Führende Autor*innen der Med Uni Graz
- Fritsch Peter
- Co-Autor*innen der Med Uni Graz
- Ehammer-Rosenkranz Andrea
- Fritsch Maria
- Mangge Harald
- Muntean Eugen
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- Abstract:
- The metabolic syndrome (MetS) is associated with central obesity and leads to increased morbidity and mortality due to cardiovascular disease (CVD). Since obesity is associated with a hypercoagulable state, it has been speculated that hypercoagulation is linking MetS to CVD. We prospectively examined 81 overweight children and 32 normal-weight children aged 10-16 years. We analyzed blood pressure, fasting lipids, glucose, insulin, fibrinogen, and thrombin generating test determining time to peak (TTPeak), peak, time preceding the thrombin burst (lag-time), and 'endogenous' thrombin potential (ETP). Overweight children demonstrated significantly higher fibrinogen levels (p<0.001), shorter lag-time (p<0.001), and TTPeak (p=0.038) compared to normal-weight children. Furthermore, ETP (p<0.001) and peak (p<0.001) were significantly higher in overweight than in normal-weight children. Fibrinogen and all parameters of the clotting test correlated significantly (p always <0.05) to body mass index (BMI) but not significantly to insulin resistance index HOMA-IR or occurrence of MetS in multiple linear backward regression analyses adjusted for age and gender. The increased fibrinogen levels and the changes in the thrombin generation test points towards a haemostatic alteration in overweight children. The parameters of the clotting test were related to the degree of overweight but not to insulin resistance or occurrence of MetS questioning a direct association between MetS and the coagulation system. Longitudinal studies are needed to confirm these findings. Copyright © 2010 Elsevier Ireland Ltd. All rights reserved.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent -
- Blood Pressure -
- Body Weight -
- Child -
- Female -
- Fibrinogen - biosynthesis
- Hemostasis -
- Humans -
- Insulin Resistance -
- Lipids - chemistry
- Male -
- Metabolic Syndrome - blood
- Obesity -
- Overweight - blood
- Prospective Studies -
- Thrombin - biosynthesis
- Find related publications in this database (Keywords)
- Thrombin generation test
- Fibrinogen
- Blood pressure
- Insulin resistance
- Obesity
- Lipids