Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Schlegel, N; Bardet, V; Kenet, G; Muntean, W; Zieger, B; Nowak-Gottl, U.
Diagnostic and therapeutic considerations on inherited platelet disorders in neonates and children.
KLIN PADIAT. 2010; 222(3): 209-214.
Doi: 10.1055/s-0030-1249065
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- Co-Autor*innen der Med Uni Graz
- Muntean Eugen
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- Abstract:
- Inherited disorders of platelets constitute a group of rare diseases that give rise to bleeding syndromes of variety severity, with more severe cases being first diagnosed during infancy and childhood. To appropriate diagnose a platelet function disorder during early childhood the knowledge of the physiological characteristics of platelets in the paediatric population is mandatory. Apart from thrombocytopenia which is quite common in neonates and children the present overview is aimed to focus on inherited platelet function disorders. Furthermore, knowledge on platelet maturation and reference values according to age are given, and a diagnostic strategy specifically adapted to a pediatric population is presented on the bases of plasmatic and molecular laboratory methodologies. Finally, therapeutic approaches are briefly summarized (antifibrinolytic agents, Desmopressin, HLA-matched platelets, recombinant factor VIIa).
- Find related publications in this database (using NLM MeSH Indexing)
- Antifibrinolytic Agents - therapeutic use
- Blood Platelet Disorders - blood
- Child -
- DNA Mutational Analysis -
- Deamino Arginine Vasopressin - therapeutic use
- Diagnosis, Differential -
- Factor VIIa - therapeutic use
- Hemorrhagic Disorders - blood
- Humans -
- Infant -
- Infant, Newborn -
- Molecular Motor Proteins - genetics
- Myosin Heavy Chains - genetics
- Partial Thromboplastin Time -
- Platelet Count -
- Platelet Function Tests -
- Platelet Transfusion -
- Recombinant Proteins - therapeutic use
- Syndrome -
- Thrombocytopenia - blood
- von Willebrand Diseases - blood
- von Willebrand Factor - metabolism
- Find related publications in this database (Keywords)
- platelet function disorders
- neonates
- infants
- children
- developmental hemostasis
- laboratory work-up