Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Stelzer, I; Fuchs, R; Schraml, E; Quan, P; Hansalik, M; Pietschmann, P; Quehenberger, F; Skalicky, M; Viidik, A; Schauenstein, K.
Decline of Bone Marrow-Derived Hematopoietic Progenitor Cell Quality During Aging in the Rat
EXP AGING RES. 2010; 36(3): 359-370.
Doi: 10.1080/0361073X.2010.484785
Web of Science
FullText
FullText_MUG
- Leading authors Med Uni Graz
- Stelzer Ingeborg
- Co-authors Med Uni Graz
- Fuchs Robert
- Quan Ping
- Quehenberger Franz
- Schauenstein Konrad
- Schraml Elisabeth
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- Several studies have shown that aging is associated with quantitative and qualitative alterations of the stem and progenitor cell compartment. The current results indicate that there is a significant age-associated decline in the proliferative capacity of rat myeloid progenitor cells. In contrast, no difference was found in the frequency of myeloid progenitor cells in the bone marrow of young versus old rats. Furthermore, a significant shift towards higher proliferative capacity of myeloid progenitors was observed after lifelong voluntary exercise. These data emphasize that aging is accompanied by a loss of proliferative capacity and that voluntary exercise could retard this process.