Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Kopp, KLM; Kauczok, CS; Lauenborg, B; Krejsgaard, T; Eriksen, KW; Zhang, Q; Wasik, MA; Geisler, C; Ralfkiaer, E; Becker, JC; Odum, N; Woetmann, A.
COX-2-dependent PGE(2) acts as a growth factor in mycosis fungoides (MF)
LEUKEMIA. 2010; 24(6): 1179-1185.
Doi: 10.1038/leu.2010.66
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- Co-authors Med Uni Graz
- Becker Jürgen Christian
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- Abstract:
- Cancer often originates from a site of persistent inflammation, and the mechanisms turning chronic inflammation into a driving force of carcinogenesis are intensely investigated. Cyclooxygenase-2 (COX-2) is an inducible key modulator of inflammation that carries out the rate-limiting step in prostaglandin synthesis. Aberrant COX-2 expression and prostaglandin E(2) (PGE(2)) production have been implicated in tumorigenesis. In this study we show that COX-2 is ectopically expressed in malignant T-cell lines from patients with cutaneous T-cell lymphoma (CTCL) as well as in situ in lymphocytic cells in 21 out of 22 patients suffering from mycosis fungoides (MF) in plaque or tumor stage. COX-2 is not expressed in lymphocytes of 11 patients with patch-stage MF, whereas sporadic COX-2 staining of stromal cells is observed in the majority of patients. COX-2 expression correlates with a constitutive production of PGE(2) in malignant T cells in vitro. These cells express prostaglandin receptors EP3 and EP4 and the receptor antagonist as well as small interfering RNA (siRNA) directed against COX-2, and specific COX-2 inhibitors strongly reduce their spontaneous proliferation. In conclusion, our data indicate that COX-2 mediated PGE(2) exerts an effect as a tumor growth factor in MF.
- Find related publications in this database (using NLM MeSH Indexing)
- Blotting, Western -
- Cell Proliferation -
- Cyclooxygenase 2 - chemistry Cyclooxygenase 2 - genetics Cyclooxygenase 2 - metabolism
- Cyclooxygenase 2 Inhibitors - pharmacology
- Enzyme-Linked Immunosorbent Assay -
- Flow Cytometry -
- Humans -
- Immunoenzyme Techniques -
- Lymphoma, T-Cell, Cutaneous - drug therapy Lymphoma, T-Cell, Cutaneous - metabolism Lymphoma, T-Cell, Cutaneous - pathology
- Mycosis Fungoides - drug therapy Mycosis Fungoides - metabolism Mycosis Fungoides - pathology
- Prostaglandins E - pharmacology
- RNA, Messenger - genetics RNA, Messenger - metabolism
- RNA, Small Interfering - pharmacology
- Receptors, Prostaglandin E - metabolism
- Receptors, Prostaglandin E, EP3 Subtype -
- Reverse Transcriptase Polymerase Chain Reaction -
- Skin Neoplasms - drug therapy Skin Neoplasms - metabolism Skin Neoplasms - pathology
- Tumor Cells, Cultured -
- Find related publications in this database (Keywords)
- COX-2
- prostaglandin
- CTCL
- diagnosis
- proliferation