Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Hackl, F; Stiegler, P; Stadlbauer, V; Schaffellner, S; Iberer, F; Matzi, V; Maier, A; Klemen, H; Smolle-Jüttner, FM; Tscheliessnigg, K.
Preoxygenation of different preservation solutions for porcine pancreas preservation.
Transplant Proc. 2010; 42(5):1621-1623
Doi: 10.1016/j.transproceed.2010.02.071
Web of Science
PubMed
FullText
FullText_MUG
Google Scholar
- Führende Autor*innen der Med Uni Graz
- Stiegler Philipp
- Co-Autor*innen der Med Uni Graz
- Iberer Florian
- Klemen Huberta
- Maier Alfred
- Matzi Veronika
- Schaffellner Silvia
- Smolle-Juettner Freyja-Maria
- Stadlbauer-Köllner Vanessa
- Tscheliessnigg Karlheinz
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- Introduction. Organ preservation quality impacts porcine islet cell isolation and transplantation success. Among several preservation methods, the two-layer method is promising, but technically demanding and fails to deliver sufficient oxygen. The use of hyperbaric oxygenation may be an easier, more effective method to supply high partial pressure of oxygen (pO(2)) for organ storage. Therefore, the aim of this study was to test the capability of preoxygenation of various preservation solutions with HBO to maintain high pO(2) levels. Methods. University of Wisconsin (UW), Custodiol, Perfadex, or Celsior solutions were preoxygenated in a pressure chamber. NaCl served as the control. pO(2) levels were measured at defined times. The oxygen storage capability was evaluated by leaving the storage bottles open for 2 minutes. Results. It was feasible to preoxygenate preservation solutions. The best solution to maintain high pO(2) tensions was Perfadex, followed by Celsior, and UW. Discussion. The greater the amount of oxygen in the preservation solution, the more oxygen can be delivered to the preserved pancreas. Further studies on the influence of preoxygenated preservation solutions on the porcine pancreas are warranted to improve organ quality, porcine islet cell isolation, and transplantation success.
- Find related publications in this database (using NLM MeSH Indexing)
- Adenosine - pharmacology
- Allopurinol - pharmacology
- Animals -
- Citrates - pharmacology
- Disaccharides - pharmacology
- Electrolytes - pharmacology
- Glutamates - pharmacology
- Glutathione - pharmacology
- Histidine - pharmacology
- Hyperbaric Oxygenation - methods
- Insulin - pharmacology
- Mannitol - pharmacology
- Organ Preservation - methods
- Organ Preservation Solutions - pharmacology
- Oxygen - pharmacology
- Pancreas - cytology Pancreas - drug effects
- Partial Pressure -
- Raffinose - pharmacology
- Swine -