Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

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SHR Neuro Krebs Kardio Lipid Stoffw Microb

Schmidt, R; Baumhackl, U; Berek, K; Brücke, T; Kapeller, P; Lechner, A; Rainer, M; Stögerer, EM.
Memantine for treatment of behavioural disturbances and psychotic symptoms in moderate to moderately severe Alzheimer dementia: a naturalistic study in outpatient services in Austria.
Neuropsychiatr. 2010; 24(2): 125-131.
PubMed

Führende Autor*innen der Med Uni Graz: Schmidt Reinhold
Co-Autor*innen der Med Uni Graz: Kapeller Peter; Lechner Anita; Stögerer-Oberschmid Eva Maria
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Abstract:: We conducted an open, 16-week study on the efficacy of memantine on behavioral disturbances and psychotic symptoms in moderate to moderately severe Alzheimer s disease in daily routine. Fifty-three patients of 20 outpatient centers in Austria were recruited. The Neuropsychiatric Inventory (NPI) was defined as main outcome measure. After 16 weeks the total NPI score improved by 4,6 points (p<0.01). The caregiver distress score was also significantly reduced. The most pronounced improvements were seen in the NPI components depression (-24,6%), aberrant motor behavior (-16,9%), agitation/agression, fear, apathy, disinhibition and disturbances in appetite and eating behavior (-11,3%, each). Our naturalistic study is in line with the results of controlled trials in moderate and severe Alzheimer dementia stages. Controlled clinical trials which have behavioral disturbances and psychotic symptoms as primary endpoint are needed to define the true potential of memantine in mild dementia stages.
Find related publications in this database (using NLM MeSH Indexing): Activities of Daily Living - classification; Aged -; Aged, 80 and over -; Alzheimer Disease - drug therapy; Ambulatory Care -; Ambulatory Care -; Caregivers - psychology; Cost of Illness -; Dopamine Agents - adverse effects; Female -; Follow-Up Studies -; Humans -; Male -; Memantine - adverse effects; Mental Disorders - drug therapy; Mental Status Schedule -; Middle Aged -; Nootropic Agents - adverse effects; Psychotic Disorders - drug therapy