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SHR Neuro Cancer Cardio Lipid Metab Microb
Olschewski, H; Hoeper, MM; Behr, J; Ewert, R; Meyer, A; Borst, MM; Winkler, J; Pfeifer, M; Wilkens, H; Ghofrani, HA; Nikkho, S; Seeger, W.
Long-term therapy with inhaled iloprost in patients with pulmonary hypertension
RESP MED. 2010; 104(5): 731-740.
Doi: 10.1016/j.rmed.2010.01.008
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- Olschewski Horst
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- Abstract:
- Aims: To investigate the long-term safety of inhaled iloprost in patients with pulmonary hypertension (pH), including idiopathic PAH (IPAH group) and other forms of pulmonary hypertension (PHother). Methods and results: Sixty-three patients (IPAH group, n = 40, PHother n = 23) were enrolled to receive inhaled iloprost either from baseline or after 3 months in a prospective, open-label 2-year study. Iloprost was inhaled 6-9 times daily with a night pause employing a jet nebulizer delivering an inhaled single dose of 4 mu g at the mouthpiece. In the case of side effects the single dose was reduced to 2 mu g. Sixty patients received at least 1 dose of inhaled iloprost. Thirty-six patients completed at least 630 days of therapy (25 IPAH, 11 PHother), 19 patients dropped out prematurely and 8 patients died (3 IPAH, 5 PHother). There were no drug-induced toxicities and only mild to moderate side effects. The most common side effects were coughing and flushing. Two-year survival was estimated at 85% (IPAH group 91%, PHother 78%). A modified analysis was performed to correct for differential drop-out. It included follow-up data from the premature discontinuations and revealed a 2-year survival of 87% [95% CI, 76%-98%] in the IPAH group while the predicted survival was 63%. The iloprost dose increased by 16% over 2 years. Conclusion: Inhaled iloprost is well tolerated as long-term therapy and no substantial dose increase is required. Although uncontrolled, the data suggest a long-term clinical benefit from continued therapy with inhaled iloprost. (C) 2010 Elsevier Ltd. All rights reserved.
- Find related publications in this database (Keywords)
- Inhaled iloprost
- Pulmonary arterial hypertension
- Long-term treatment
- Hypertension
- pulmonary
- Survival