Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Hanzer, M; Nebl, A; Spendel, S; Pilhatsch, A; Urban, C; Benesch, M.
Necrosis of a skin autograft after short-term treatment with sunitinib in a 14-year-old girl with metastatic alveolar soft part sarcoma of the thigh.
Klin Padiatr. 2010; 222(3): 184-186.
Doi: 10.1055/s-0030-1249093
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- Leading authors Med Uni Graz
- Hausegger Marie
- Co-authors Med Uni Graz
- Benesch Martin
- Nebl Andrea Maria
- Spendel Stephan
- Urban Ernst-Christian
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- Abstract:
- A 14-year-old girl was diagnosed with alveolar soft part sarcoma (ASPS) of the thigh and lung metastases. She underwent tumor resection and pulmonary metastasectomy followed by hyperfractionated local radiotherapy (44.8 Gy). A mesh graft transplant was used to cover the postoperative skin defect on the thigh. Since ASPS do not respond to conventional chemotherapy antiangiogenic treatment with peginterferon alfa-2b and thalidomide was started. Immunohistochemical analysis of tumor tissue showed expression of vascular endothelial growth factor receptors (VEGFR) 1, 2, 3, and platelet derived growth factor receptor (PDGFR)-alpha and -beta. Hence, additional treatment with multitargeted receptor tyrosine kinase inhibitor sunitinib (Sutent) was started on a compassionate use basis. 2 weeks later the patient presented with necrosis of the skin transplant requiring necrectomy and skin grafting. This case illustrates that drugs inhibiting vascular endothelial growth factor receptors have to be used very cautiously in cancer patients with severe pre-existing skin damage.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent -
- Angiogenesis Inhibitors - adverse effects
- Antineoplastic Agents - adverse effects
- Chemotherapy, Adjuvant -
- Combined Modality Therapy -
- Compassionate Use Trials -
- Female -
- Follow-Up Studies -
- Humans -
- Indoles - adverse effects
- Lung Neoplasms - drug therapy
- Necrosis -
- Postoperative Complications - chemically induced
- Pyrroles - adverse effects
- Radiotherapy, Adjuvant -
- Reoperation -
- Sarcoma, Alveolar Soft Part - drug therapy
- Skin Transplantation -
- Soft Tissue Neoplasms - drug therapy
- Surgical Flaps - blood supply
- Thigh - surgery
- Find related publications in this database (Keywords)
- alveolar soft part sarcoma
- sunitinib
- skin toxicity
- targeted therapy