Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Peris, K; Cerroni, L; Kerl, H; Radaszkiewicz, T; Chimenti, S; Höfler, H.
Expression of c-myc in cutaneous lymphomas and pseudolymphomas.
DERMATOLOGICA 1991 183: 1-6.
Doi: 10.1159/000247622
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- Co-Autor*innen der Med Uni Graz
- Cerroni Lorenzo
- Kerl Helmut
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- Abstract:
- The expression of the proto-oncogene c-myc was studied in tumorous skin lesions of (cutaneous) lymphoproliferative diseases (3 cases of pseudolymphoma, 8 cases of non-Hodgkin lymphoma and 1 case of lymph node involvement in mycosis fungoides) in a total of 12 patients. c-myc mRNA levels were quantified by Northern blot analysis followed by densitometric evaluation of the specific bands. Higher levels of c-myc mRNA expression were observed in lymphomas as compared with pseudolymphomas (p greater than 0.05). No significant differences in c-myc mRNA values were detected between B and T cell pseudolymphomas. Our results suggest that c-myc mRNA overexpression is associated with malignant lymphomas of the skin. We conclude that the measurement of c-myc mRNA levels may contribute to further characterize cutaneous lymphoproliferative diseases.
- Find related publications in this database (using NLM MeSH Indexing)
- Blotting, Northern -
- Humans -
- Lymphoma - genetics
- Proto-Oncogene Proteins c-myc - genetics
- RNA, Messenger - analysis
- Skin Neoplasms - genetics
- Find related publications in this database (Keywords)
- Cutaneous Lymphomas
- Pseudolymphomas
- C-myc