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SHR Neuro Cancer Cardio Lipid Metab Microb
Schober, E; Rami, B; Waldhoer, T; Austrian Diabetes Incidence Study Group.
Diabetic ketoacidosis at diagnosis in Austrian children in 1989-2008: a population-based analysis.
Diabetologia. 2010; 53(6): 1057-1061.
Doi: 10.1007/s00125-010-1704-1
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- Abstract:
- The aim of the study was to analyse the prevalence of diabetic onset ketoacidosis (DKA) during a period of 20 years (1989-2008) on a population basis in the whole of Austria. A prospective population-based incidence study (1989-2008) was performed. The registered data set comprised blood glucose, pH, ketonuria and clinical symptoms of DKA at manifestation. DKA was defined as pH < 7.3 and severe DKA as pH < 7.1. Time trends were estimated using linear regression models. During the study period, 3331 children < 15 years of age (1,797 boys and 1,534 girls) were registered with newly diagnosed type 1 diabetes. Of these, 1,238 (37.2%) presented with DKA, 855 (25.7%) had a mild and 383 (11.5%) a severe form, and one patient died at onset. DKA frequency was negatively associated with age at onset (p < 0.0001). In children < 2 years the prevalence was 60%, with a higher risk for girls (70% vs 54% for boys, p < 0.05). Despite a significant increase in diabetes incidence in Austria during the observation period from 8.4 to 18.4/100,000 (p < 0.0001), no significant change in the prevalence of DKA at manifestation was observed. The overall frequency of DKA in children with newly diagnosed type 1 diabetes in Austria is high and has not changed during the last 20 years despite a clear increase in the manifestation rate. In particular, children less than 2 years of age have a high risk of DKA at onset.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent -
- Age Factors -
- Age of Onset -
- Age of Onset - epidemiology
- Blood Glucose -
- Child -
- Child, Preschool -
- Diabetes Mellitus, Type 1 - diagnosis
- Diabetic Ketoacidosis - diagnosis
- Female -
- Humans -
- Incidence -
- Infant -
- Infant, Newborn -
- Male -
- Prevalence -
- Prospective Studies -
- Regression Analysis -
- Severity of Illness Index -
- Find related publications in this database (Keywords)
- Austria
- Children
- Diabetes manifestation
- Diabetic ketoacidosis
- Time trend
- Type 1 diabetes mellitus