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Gattenlohner, S; Bonengel, M; Muller-Hermelink, HK.
Optimized RT-PCR based detection of specific genetic abnormalities within malignant hematopoietic disorders.
Pathologe. 2006; 27(3):182-187 Doi: 10.1007/s00292-005-0750-9
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Leading authors Med Uni Graz: Gattenlöhner Stefan
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Abstract:: The moleculargenetic detection of specific genetic abnormalities within malignant hematopoietic disorders is an important diagnostic tool with relevance for the differential diagnosis, therapy and prognosis.According to a modified and optimized RT-PCR based technique native bone marrow aspirates and peripheral blood samples of 183 patients were investigated for the presence of specific genetic abnormalities. The histological diagnosis of all CMLs t(9;22) and variants of AMLs M3 t(15;17) and t(11;17) were moleculargenetically confirmed. Additionally one t(5;12) positive chronic myelomonozytic leukemia, one t(8;21) positive AML M1, one t(9;22) positive B-ALL and in each case one t(6;9) and one t(3;21) positive myelodysplastic syndrome were detected. The hereby described method is a simple, specific and reliable technique for the rapid moleculargenetic detection of specific genetic abnormalities within malignant hematopoietic disorders with implication for the diagnosis/differential diagnosis, prognosis and therapy.
Find related publications in this database (using NLM MeSH Indexing): Gene Expression Regulation, Neoplastic -; Genetic Diseases, Inborn - genetics Genetic Diseases, Inborn - pathology; Hematologic Neoplasms - genetics Hematologic Neoplasms - pathology; Humans -; Reverse Transcriptase Polymerase Chain Reaction -
Find related publications in this database (Keywords): malignant hematopoietic disorders; genetic abnormalities; moleculargenetic techniques; polymerase chain reaction