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Gattenlohner, S; Muller-Hermelink, HK; Marx, A.
Transcription of the nude gene (WHN) in human normal organs and mediastinal and pulmonary tumors.
Pathol Res Pract. 1999; 195(8):571-574 Doi: 10.1016/S0344-0338(99)80007-7
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Leading authors Med Uni Graz: Gattenlöhner Stefan
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Abstract:: Mutations in the winged-helix-nude (WHN) gene in the nude mouse and rat phenotypes lead to loss of hair and athymia. The human nude gene has recently been identified, but to date, its distribution in normal human tissues and thymus tumors has not yet been investigated. We used the RT-PCR technique for the detection of WHN transcripts in normal human organs and various mediastinal tumors, including various subtypes of thymic epithelial tumors. We could show that WHN is highly transcribed in the normal thymus and skin. Unexpectedly, few transcripts were also found in the normal kidney and thyroid gland. WHN mRNA could be detected in all thymoma subtypes (n = 14) and epidermoid thymic carcinomas as well as in all squamous cell carcinomas of the lung (n = 5) investigated, but was totally absent in all other mediastinal tumors (n = 11) lacking an epidermoid differentiation. We conclude that transcription of the human WHN is not strictly specific for human thymus and skin, but is also expressed, though at very low levels, in the normal human kidney and thyroid gland. In addition, WHN gene expression may identify not only thymomas but also epidermoid differentiation in mediastinal and pulmonary tumors.
Find related publications in this database (using NLM MeSH Indexing): Adenocarcinoma - genetics Adenocarcinoma - metabolism; Carcinoma, Squamous Cell - genetics Carcinoma, Squamous Cell - metabolism; DNA-Binding Proteins - biosynthesis DNA-Binding Proteins - genetics; Forkhead Transcription Factors -; Germinoma - genetics Germinoma - metabolism; Humans -; Kidney - metabolism; Lung Neoplasms - genetics Lung Neoplasms - metabolism; Lymphoma, B-Cell - genetics Lymphoma, B-Cell - metabolism; Mediastinal Neoplasms - genetics Mediastinal Neoplasms - metabolism; Organ Specificity - genetics; RNA, Messenger - biosynthesis; Reverse Transcriptase Polymerase Chain Reaction -; Skin - metabolism; Thymoma - genetics Thymoma - metabolism; Thymus Gland - metabolism; Thymus Neoplasms - genetics Thymus Neoplasms - metabolism; Thyroid Gland - metabolism; Transcription Factors - biosynthesis Transcription Factors - genetics; Transcription, Genetic -
Find related publications in this database (Keywords): nude gene; WHN; human; mediastinal tumors; thymic epithelial tumors