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Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Volker, HU; Engert, S; Cramer, A; Schmidt, M; Kammerer, U; Muller-Hermelink, HK; Gattenlohner, S.
Expression of CD56 isoforms in primary and relapsed adult granulosa cell tumors of the ovary
DIAGN PATHOL. 2008; 3: 29
Doi: 10.1186/1746-1596-3-29
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- Co-authors Med Uni Graz
- Gattenlöhner Stefan
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- Abstract:
- Background: Adult granulosa cell tumors of the ovary (GCTs) are sex cord stromal tumors of unpredictable behaviour. Up to now, the prediction of the relapsing/malignant potential remains difficult. CD56 (NCAM) in GCTs was previously described in only two studies. However, the expression of its isoforms was not examined. Methods: 30 GCTs (16 primaries, 14 relapses) were investigated immunohistochemically with antibodies against Pan-CD56 (CD56(Pan)) and the isoform with 140/180 kDa length (CD56(140/180) (kDa)). The reaction was assessed with respect to percentage of positive cells and intensity of staining. Results: In all GCTs, CD56(Pan) was expressed, but differences were found between primaries and relapses. The percentage of CD56(Pan) positive tumor cells was lower in relapses, whereas CD56(140/180 kDa) showed a higher staining intensity in the latter. Conclusion: Expression of CD56 is an additional sensitive and helpful immunohistochemical tool for histopathologists diagnosing a GCT. It does not seem possible to provide a validly individual risk assessement. However, the different expression of CD56 isoforms might indicate important changes in the course to a more malignant behaviour.